Monobactam (Other Beta-lactam antibiotic except Penicillin and Cephalosporin)
Indication: Atreon is indicated in the treatment of the following infections caused by susceptible aerobic Gram-negative micro-organisms- Urinary tract infections: Pyelonephritis, cystitis (initial and recurrent) and asymptomatic bacteriuria (including those due to pathogens resistant to the aminoglycosides, cephalosporins or penicillins). Gonorrhea: Acute uncomplicated urogenital or anorectal infections. Lower respiratory tract infections: Including pneumonia, bronchitis and lung infections in patients with cystic fibrosis. Skin and soft tissue infections: Postoperative wounds, ulcers and burns.
Meningitis: Caused by Haemophilus influenzae or Neisseria meningitidis.
Gynecological infections: Pelvic Inflammatory Disease (PID), endometritis and pelvic cellulitis. Intra-abdominal infections: Peritonitis. Bacteremia/septicemia: Septicemia caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Serratia marcescens and Enterobacter species. Bone and joint infections: Osteomyelitis, septic arthritis. Aztreonam is also indicated for adjunctive therapy to surgery in the management of infections caused by susceptible organisms. Patients with serious Pseudomonas infections may benefit from

Dosage & Administration:
The usual dose of Aztreonam is 3 to 4 gm daily (maximum recommended dose is 8 gm daily). The dosage and route of administration should be determined by the susceptibility of the causative organisms, severity of infection and the condition of the patient. In case of Pseudomonas aeruginosa infections, 2 gm every 6 or 8 hours is recommended.

The usual dosage for patients older than one week is 30 mg/kg/dose every 6 or 8 hours. For severe infections in patients 2 years of age or older, 50 mg/kg/dose every 6 or 8 hours is recommended. Dosage information is not yet available for new-born less than 1 week old.

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