Treatment and prevention of glucocorticoid-induced osteoporosis:
Recommended dose is a single intravenous infusion of 5 mg Zoledronic Acid administered once a year. Adequate supplement calcium and Vitamin-D intake is important in patients with osteoporosis if dietary intake is inadequate.
Treatment of paget’s disease of bone:
Recommended dose is a single intravenous infusion of 5 mg Zoledronic Acid. Re-treatment with Zoledronic Acid may be considered in patients who have relapsed, based on increases in serum alkaline phosphatase, in patients who failed to achieve normalization of serum alkaline phosphatase, or in patients with symptoms, as dictated by medical practice 12 months after the initial dose.
In patients with paget’s disease, adequate vitamin-D intake is recommended in association with Zoledronic Acid administration. In addition, it is strongly advised that adequate supplemental calcium corresponding to at least 500 mg elemental calcium twice daily is ensured in patients with paget’s disease for at least 10 days following Zoledronic Acid administration.
BonizolTM should be administered intravenously via an infusion line, given at a constant infusion rate. The infusion time must not be less than 15 minutes.
Special dosage instruction
Patients with renal impairment:The use of Zoledronic Acid in patients with creatinine clearance <35 mL\min is not recommended due to limited clinical safety data in such patients. No dose adjustment is is necessary in patients with creatinine clearance >35 mL\min.
Patients with hepatic impairment: No dose adjustment is required for patients with hepatic impairment.
Elderly patients: No dose adjustment is required. However because decreased renal function occurs more common in the elderly, special care should be taken to monitor renal function.
BonizolTM IV Infusion: Each pack contains a single 100 ml glass bottle containing Zoledronic Acid INN 5 mg. Hanger, Butterfly needle, Alcohol pad, First aid bandage, Infusion set is given in each pack.
Bone Calcium Regulator
Zoledronic Acid 5 mg solution for infusion