Healthcare online Keeping you up-to-date
VOL.  18     ISSUE:  6  June  2020 Medical Services Department

SQUARE Pharmaceuticals Ltd.





P G Dip. Business Management



Rubyeat Adnan



Dear Doctor:

Welcome to this edition of 'e-SQUARE' !

Hope you are enjoying this version of online healthcare bulletin  !

This issue features the articles including-

 "Eczema Treatment !", "Cancer Mortality Predicts !", "Dietary Restriction !", "Depression Linked to CVD !", "Early Psychosis !", "Brain Cell Links & Aging !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals Ltd. as well.

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Editorial Team

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The views expressed in this publication do not necessarily reflect those of its editor or SQUARE PHARMACEUTICALS LTD.

Eczema Treatment !

                                                                                               Novel approach for treating eczema

Researchers have identified a key enzyme that contributes to eczema, which may lead to better treatment to prevent the skin disorder's debilitating effects. The Granzyme B enzyme is positively correlated with itchiness and disease severity in eczema. Researchers found that Granzyme B weakens the skin barrier by cleaving through the proteins holding cells together making it easier for allergens to penetrate across & they found that by knocking out Granzyme B with genetic modification, or inhibiting it with a topical gel, they could prevent it from damaging the skin barrier and significantly reduce the severity of AD (Atopic dermatitis). Previous work had suggested that Granzyme B levels correlate with the degree of itchiness and disease severity in patients with atopic dermatitis. AD is also associated with an increased risk of developing a host of other inflammatory conditions, including food allergies, asthma and allergic rhinitis. AD typically follows an itch-scratch cycle in which itchiness is followed by scratching and more itchiness. This cycle usually occurs during flare-ups, which can appear anytime, and sometimes weeks, months or years apart. Corticosteroid creams are a common treatment for individuals with AD who experience more severe itching and rashes. However, these can thin the skin when used over a prolonged period of time, which can make skin more prone to damage and infection. A gel or cream that stops or limits Granzyme B, thereby reducing the severity of AD, could be a safer and more effective long-term treatment.

SOURCE: Science Daily News, June 2020

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Cancer Mortality Predicts !

                                     Sedentary behavior independently predicts cancer mortality

The most sedentary individuals had an 82% higher risk of cancer mortality compared to the least sedentary individuals. An accelerometer was used to measure physical activity, rather than relying on participants to self-report their activity levels. Researchers also found that replacing 30 minutes of sedentary time with physical activity was associated with a 31% lower risk of cancer death for moderate-intensity activity, such as cycling, and an 8% lower risk of cancer death for light-intensity activity, such as walking. The study also found that engaging in either light or moderate to vigorous physical activity made a difference. Investigators assessed sedentary time, light-intensity physical activity (LIPA) and moderate to vigorous physical activity (MVPA) in the same model and found that LIPA and MVPA, not sedentary behavior, remained significantly associated with cancer mortality. Researcher said from a practical perspective, this means that individuals who replaced either 10 to 30 minutes of sedentary time with either LIPA or MVPA had a lower risk of cancer mortality in the REGARDS cohort. The study had several limitations, including a potentially healthier participant sample compared to the full REGARDS cohort and a lack of site-specific cancer data, including type of tumor and treatment & reinforce that it's important to 'sit less and move more' and that incorporating 30 minutes of movement into your daily life can help reduce your risk of death from cancer.

SOURCE: Science Daily News, June 2020

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Dietary Restriction !

Essential components of dietary restriction revealed

Studies have provided a new understanding into the roles two essential amino acids play in metabolic health, which may help scientists in the fight against obesity. Recent finding shows that by reducing the amount of two amino acids threonine and tryptophan in young healthy mice, they were able to burn more calories than they consumed, without calorie reduction, keeping them lean and healthy and without the side-effect of lower muscle mass. A low-threonine diet even protected mice that were morbidly obese and prone to developing type 2 diabetes. While a moderate reduction in dietary protein and therefore essential amino acids can enhance vitality, diets devoid of this component can make people sick very quickly and are not recommended. However, this study has shown that a reconsideration of the functions of these two amino acids in nutrition warrants further exploration. Researcher said that from this study they understand which particular dietary components are needed for the health-promoting effects of these diets we can design strategies to mimic them, simulating the effects without having the negative side effects. A highlight of the study was an experiment genetically manipulated the mice to be able to synthesise the essential amino acid threonine, which blocked the health promoting effects of the low threonine diet and saw the mice gain weight, proving that these two amino acids can hold the key to a new diet approach..

SOURCE: Science Daily News, June 2020

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Depression Linked to CVD !

                                 Depression associated with greater risk of cardiovascular disease (CVD)

A new study link between depressive symptoms and an increased risk of heart disease and early death. The global study tracked 145,862 middle-aged participants from 21 countries and found a 20 per cent increase in cardiovascular events and death in people with four or more depressive symptoms. The risks were twice as high in urban areas where the majority of the global population will be living by 2050 and more than double in men. Researcher said that the results are timely as experts anticipate an increase in the number of people dealing with mental health issues as a result of the COVID-19 pandemic. The data suggests that depressive symptoms should be considered as important as traditional risk factors such as smoking, high blood pressure and high cholesterol when preventing heart disease and early death. The study concludes that a greater awareness of the physical health risks associated with depression is needed. Researchers suggest that a comprehensive approach to tackling non-communicable diseases and mental disorders to achieve health-related UN Sustainable Development Goals needs to be a global priority.

SOURCE: Science Daily News, June 2020

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Early Psychosis !

 Early psychosis may not require antipsychotic medications to recover

Researchers have found that some young people with early stage first episode psychosis (FEP) can experience reduced symptoms and improve functioning without antipsychotic medication when they are provided with psychological interventions and comprehensive case management. The Staged Treatment and Acceptability Guidelines in Early Psychosis (STAGES) study compared two groups of young people, aged 15 -- 25 years, presenting with FEP to a specialist early psychosis service. Both groups received intensive psychosocial intervention, with one group also receiving low dose antipsychotic medication and the other receiving a placebo. The study found that the addition of antipsychotic medication to intensive psychosocial intervention did not lead to superior outcomes in symptoms and functioning within the first six months, suggesting that antipsychotic medication may not be needed early in the course of illness for all people within the spectrum of psychosis. Current practice recommends anti-psychotic medication be taken from the outset of psychotic illness in order to achieve rapid recovery and improvement of psychotic symptoms. Researcher said that for many young people with early stage FEP, medication is an essential part of their treatment plan. But, for those young people who do not want medication, psychological interventions and comprehensive case management could be a feasible model of treatment.

SOURCE: Science Daily News, June 2020

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Brain Cell Links & Aging !

                                          Clues to aging come to light in vivid snapshots of brain cell links

The colourful pictures of the whole mouse brain at different ages are the first of their kind and a pivotal step forward in understanding behaviour, scientists say. Findings could shed light on learning disability and dementia and help to reveal how memories are affected by age. The images are of synapses -- vital connections that carry electrical and chemical messages between brain cells. Synapses store memories and synapse damage is linked to more than 130 brain diseases. Researchers colour-coded the different types of molecules to highlight the range of synapses in mouse brains from birth to old age. They discovered that the number and molecular makeup of synapses shifts with age in different parts of the brain. This happens at three main phases -- childhood, middle and elderly age. Synapse type shifts with age in patterns unique to areas of the brain, blossoming into a diverse array in midlife. Images from middle-aged brains burst with colour, illustrating a wide variety of synapses. Both very young and very old brain show less synapses and less complexity. Researchers say these changes give insights into why genes cause synapse damage at set ages and in set brain areas. The findings could shed light on why we are more likely to develop brain conditions at certain ages, helping to explain why schizophrenia often starts in adolescence, or why dementia affects older adults.

SOURCE: Science Daily News, June 2020

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Products of SQUARE Pharmaceuticals Ltd.

  Product AliceTM
Generic Name Ivermectin
  Strength 6 mg & 12 mg
Dosage form Tablet
  Therapeutic Category Anti-parasitic/ Anthelmintic
  Product Favinil TM
Generic Name



200 mg

Dosage form Tablet
Therapeutic Category Anti viral
  Product EmjardTM M
  Generic Name Empagliflozin + Metformin HCl
Strength Empagliflozin 5 mg + Metformin HCl 500 mg
Dosage form Tablet
  Therapeutic Category Antidiabetic

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