Healthcare online Keeping you up-to-date
VOL.  18     ISSUE:  5   May 2020 Medical Services Department

SQUARE Pharmaceuticals Ltd.






P G Dip. Business Management



Rubyeat Adnan




Hope that you are enjoying this online healthcare bulletin.

Our current issue focused on some interesting features like -

"COVID-19 Cocktail !", "COVID-19 & Dietary Selenium !", "Brain Insulin Sensitivity !", "Electronic Skin !",   .

In our regular feature, we have some products information of SQUARE Pharmaceuticals Ltd. as well.

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Editorial Team

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The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals Ltd.

COVID-19 Cocktail !

Supportive management for COVID-19

The world is currently experiencing the pandemic of coronavirus (CoV). Nutrition is intricately linked to immunity and to the risk and severity of infections. Conversely, chronic or severe infections lead to nutritional disorders or worsen the nutritional status of affected people. Therefore, it is imperative for all of us to pay attention to our diet and nutritional status during the ongoing COVID-19 pandemic. While there is very limited data (and none specific for COVID-19), the following “cocktail” may have a role in the prevention/mitigation of COVID-19 disease. While there is no high level evidence that this cocktail is effective; it is cheap, safe and widely available. Zinc is a component of many enzymes and transcription factors in cells all over the body, and inadequate zinc levels limit the individual’s ability to mount an adequate immune response to infections. Multiple meta-analyses and pooled analyses of randomized controlled trials (RCTs) have shown that oral zinc supplementation reduces the incidence rate of acute respiratory infections by 35%, shortens the duration of flu-like symptoms by approximately 2 days, and improves the rate of recovery. Vitamin C is a cofactor for many enzymes. It enhances the function of many enzymes all over the body by keeping their metal ions in the reduced form. It also acts as an antioxidant, limiting inflammation and tissue damage associated with immune responses. Study shows that vitamin C supplementation was shown to significantly reduce the incidence of respiratory tract infections. Evidence from several clinical trials and pooled studies show that Vitamin D supplementation lowers the odds of developing acute respiratory tract infections (most of which are assumed to be due to viruses) by 12% to 75%. These studies included both the seasonal and pandemic flu caused by H1N1 virus in 2009. The beneficial effect of supplementation was seen in patients across all ages, and individuals with pre-existing chronic illnesses. Melatonin, a well-known anti-inflammatory and anti-oxidative molecule, is protective against ALI/ARDS caused by viral and other pathogens. Melatonin is effective in critical care patients by reducing vessel permeability, anxiety, sedation use, and improving sleeping quality, which might also be beneficial for better clinical outcomes for COVID-19 patients. Notably, melatonin has a high safety profile. There is significant data showing that melatonin limits virus-related diseases and would also likely be beneficial in COVID-19 patients.

SOURCE: harvard.edu News, May 2020

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COVID-19 & Dietary Selenium !

Link identified between dietary selenium and outcome of COVID-19 disease

An international team of researchers, has identified a link between the COVID-19 cure rate and regional selenium status in China. Selenium is an essential trace element obtained from the diet (i.e. fish, meat and cereals) which has been found to affect the severity of a number of viral diseases in animals and humans. Examining data from provinces and municipalities with more than 200 cases and cities with more than 40 cases, researchers found that areas with high levels of selenium were more likely to recover from the virus. For example, in the city of Enshi in Hubei Province, which has the highest selenium intake in China, the cure rate (percentage of COVID-19 patients declared 'cured') was almost three-times higher than the average for all the other cities in Hubei Province. By contrast, in Heilongjiang Province, where selenium intake is among the lowest in the world, the death rate from COVID-19 was almost five-times as high as the average of all the other provinces outside of Hubei. Most convincingly, the researchers found that the COVID-19 cure rate was significantly associated with selenium status, as measured by the amount of selenium in hair, in 17 cities outside of Hubei. The correlation have identified is compelling, particularly given previous research on selenium and infectious diseases. As such, a careful and thorough assessment of the role selenium may play in COVID-19 is certainly justified and may help to guide ongoing public-health decisions. The research holds promise as a more effective strategy to overcome cancer therapy resistance and immune escape that can be used in combination with other cancer therapies including chemotherapy, radiation, and immunotherapy for patients with leukemia and other types of cancer.

SOURCE: Science Daily News, May 2020

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Brain Insulin Sensitivity !

Brain insulin sensitivity determines body weight and fat distribution

Just where fat is deposited in the body and to what degree a person may benefit from a lifestyle intervention depends, among other things, on how sensitive the brain is to insulin. If the person's brain responds sensitively to the hormone, a significant amount of weight can be lost, unhealthy visceral fat reduced, and the weight loss can be maintained over the long term. However, If the person's brain responds only slightly or not at all to insulin, the person only loses some weight at the beginning of the intervention and then experiences weight regain. Over the long term, the visceral fat also increases. Researcher suggest that brain insulin responsiveness could play an important role here. They showed that people with a high insulin sensitivity in the brain benefit significantly more from a lifestyle intervention with a diet rich in fiber and exercise than people with insulin resistance in the brain. Not only did they lose more weight, they also had a healthier fat distribution. It was found that insulin action in the brain not only determines body weight, but also the distribution of fat in the body. Since the insulin action in the hypothalamus is crucial for the regulation of peripheral energy metabolism, the researchers also investigated how insulin sensitivity in this area of the brain is related to the distribution of body fat. For this purpose, they examined a cross-sectional cohort of 112 participants. The analysis of the data showed that people with high insulin sensitivity in the hypothalamus form little visceral fat. However, insulin sensitivity has no influence on the mass of subcutaneous fat. Researcher said that this study reveals a novel key mechanism that regulates fat distribution in humans.

SOURCE: Science Daily News, May 2020

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Electronic Skin !

                                       Electronic skin fully powered by sweat can monitor health

One of the ways we experience the world around us is through our skin. From sensing temperature and pressure to pleasure or pain, the many nerve endings in our skin tell us a great deal. Researcher wants to learn even more about skin, and to that end, developed an electronic skin, or e-skin, that is applied directly on top of your real skin. The e-skin, made from soft, flexible rubber, can be embedded with sensors that monitor information like heart rate, body temperature, levels of blood sugar and metabolic byproducts that are indicators of health, and even the nerve signals that control our muscles. It does so without the need for a battery, as it runs solely on biofuel cells powered by one of the body's own waste products. Researcher explains that human sweat contains very high levels of the chemical lactate, a compound generated as a by-product of normal metabolic processes, especially by muscles during exercise. The fuel cells built into the e-skin absorb that lactate and combine it with oxygen from the atmosphere, generating water and pyruvate, another by-product of metabolism. As they operate, the biofuel cells generate enough electricity to power sensors and a Bluetooth device similar to the one that connects your phone, allowing the e-skin to transmit readings from its sensors wirelessly. While near-field communication is a common approach for many battery-free e-skin systems, it could be only used for power transfer and data readout over a very short distance & Bluetooth communication consumes higher power but is a more attractive approach with extended connectivity for practical medical and robotic applications. Devising a power source that could run on sweat was not the only challenge in creating the e-skin, it also needed to last a long time with high power intensity with minimal degradation. The biofuel cells are made from carbon nanotubes impregnated with a platinum/cobalt catalyst and composite mesh holding an enzyme that breaks down lactate. Researcher plan is to develop a variety of sensors that can be embedded in the e-skin so it can be used for multiple purposes.

SOURCE: Science Daily News, May 2020

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Products of SQUARE Pharmaceuticals Ltd.

  Product Quinivir TM
  Generic Name Hydroxychloroquine Sulfate

200 mg

Dosage form Tablet
  Therapeutic Category Anti- malarial
Product Filfresh TM
Generic Name


Strength 3 mg
Dosage form Tablet
Therapeutic Category Other Hormones
  Product Zifolet TM
Generic Name Folic Acid and Zinc Sulfate Monohydrate
  Strength Folic Acid BP 5 mg & Zinc Sulfate Monohydrate USP 54.90 mg equivalent to elemental Zinc 20 mg
Dosage form Tablet
  Therapeutic Category Haematinics

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