Healthcare online Keeping you up-to-date
VOL. 19  ISSUE:  4  April  2021 Medical Services Department

SQUARE Pharmaceuticals Ltd.





P G Dip. Business Management



Rubyeat Adnan





Dear Doctor,

Welcome to our healthcare bulletin 'e-SQUARE' !

Our current issue focused on some interesting features like -

"Anti-aging Intervention !", "Cancer Protien !", "CVS Benefits !", "Endocrine Disruptors !,  "Female Protective Effect !", "Less Anxious Adults !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals Ltd. as well.

We will appreciate your feedback !

Click on to reply mode.

Yours sincerely,


Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals Ltd.

Anti-aging Intervention !

                          Anti-aging compound improves muscle glucose metabolism

Researchers have found that the compound NMN (nicotinamide mononucleotide) previously demonstrated to counteract aspects of aging and improve metabolic health in mice also has clinically relevant effects in people. A small clinical trial of postmenopausal women with prediabetes shows that the compound NMN improved the ability of insulin to increase glucose uptake in skeletal muscle, which often is abnormal in people with obesity, prediabetes or Type 2 diabetes. NMN also improved expression of genes that are involved in muscle structure and remodeling. However, the treatment did not lower blood glucose or blood pressure, improve blood lipid profile, increase insulin sensitivity in the liver, reduce fat in the liver or decrease circulating markers of inflammation as seen in mice. NMN is involved in producing an important compound in all cells, called nicotinamide adenine dinucleotide (NAD). NAD plays a vital role in keeping animals healthy. Levels of NAD decline with age in a broad range of animals, including humans, and the compound has been shown to contribute to a variety of aging-associated problems, including insulin resistance in studies conducted in mice. Supplementing animals with NMN slows and ameliorates age-related decline in the function of many tissues in the body. Although study shows a beneficial effect of NMN in skeletal muscle but the researchers caution that more studies are needed to determine whether NMN has beneficial effects in the prevention or management of prediabetes or diabetes in people.

SOURCE: Science Daily News, April 2021

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Cancer Protien !

                        'Undruggable' cancer protein becomes druggable

Researcher has found a way to synthesize a compound to fight a previously "undruggable" cancer protein with benefits across a myriad of cancer types. The compound curcusone D has the potential to help combat a protein found in many cancers, including some forms of breast, brain, colorectal, prostate, lung and liver cancers, among others. The protein, dubbed BRAT1, had previously been deemed "undruggable" for its chemical properties. Researchers linked curcusone D to BRAT1 and validated curcusone D as the first BRAT1 inhibitor. Curcusones are compounds that come from a shrub named Jatropha curcas, also called the purging nut. Native to the Americas, it has spread to other continents, including Africa and Asia. The plant has long been used for medicinal properties including the treatment of cancer as well as being a proposed inexpensive source of biodiesel. Researchers tested the compounds on breast cancer cells and found curcusone D to be extremely effective at shutting down cancer cells. One difficulty in studying curcusones as potential cancer treatments is that, while the shrub they come from is common and inexpensive, it takes massive amounts of the shrub to yield even a small amount of the compounds. Even then, it is difficult to separate the compounds from the rest of the chemicals in the shrub's roots. In nature, the plant doesn't produce a lot of this compound, that's why a new synthesis is so important. The next step will be to test the compound to ensure that it is not toxic to humans, something the researchers are optimistic about since the shrub it came from has been used as a traditional medicine in a number of cultures. Already, researchers from other entities have reached out to test the compound on the cancers they study, bringing hope for renewed therapeutics for treating the disease.

SOURCE: Science Daily News, April 2021

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CVS Benefits !

                                             Leisure physical activity is linked with health benefits

The first large study showing that leisure time physical activity and occupational physical activity have opposite, and independent, associations with cardiovascular disease risk and longevity. The World Health Organization (WHO) recommends physical activity during both recreation and work to improve health. Previous studies have suggested that occupational activity is related to an increased risk for heart disease and mortality but have been too small to fully explain whether this was due to the manual work or because employees had unhealthy lifestyles or low socioeconomic status . Participants completed questionnaires about activity during leisure and employment and were categorised as low, moderate, high, or very high activity for each. During a median follow-up of 10 years, there were 9,846 (9.5%) deaths from all causes and 7,913 (7.6%) major adverse cardiovascular events (MACE, defined as fatal and nonfatal myocardial infarction, fatal and non-fatal stroke, and other coronary death).Compared to low leisure time physical activity, after adjustment for age, sex, lifestyle, health, and education, moderate, high, and very high activity were associated with 26%, 41%, and 40% reduced risks of early death, respectively. In contrast, compared to low work activity, high and very high activity were associated with 13% and 27% increased risks of death, respectively. Similarly, after adjustments, compared to low leisure activity, moderate, high, and very high levels of leisure activity were associated with 14%, 23%, and 15% reduced risks of MACE, respectively. Compared to low work activity, high and very high levels were associated with 15% and 35% increased risks of MACE, respectively. Work activity often does not sufficiently increase heart rate to improve fitness. In addition, work involving lifting for several hours a day increases blood pressure for many hours, which is linked with heart disease risk, while short bursts of intense physical activity during leisure raises blood pressure only briefly.

SOURCE: Science Daily News, April 2021

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Endocrine Disruptors !

                              Endocrine disruptors threatens semen quality

A growing number of studies show that the environmental factors and lifestyle habits of pregnant women play an important role in the health of their child. Endocrine disrupters are chemical substances of natural or synthetic origin which can interfere with the endocrine system and causes adverse health effects in an organism, or its progeny, according to the World Health Organization (WHO). Several animal studies have already shown that gestational exposure to certain endocrine disruptors can influence the development of the male reproductive system, as well as the sperm production and semen quality in adulthood. Researcher has evaluated semen quality of around 3000 conscripts, 1045 out of which had their mother working during pregnancy. This allowed for the analysis of semen parameters of men whose mothers were employed during their pregnancy. The results of this study show that young men exposed in utero to endocrine disruptors are twice as likely to have values below the reference values established by the WHO, both in terms of the semen volume. These observations do not determine the future fertility of young men, and only a follow-up over time will make it possible to assess the consequences. The results of this study suggest an association between the mother's occupational exposure to endocrine disruptors and a decrease in several semen parameters in their children during adulthood. It therefore appears necessary to inform women planning to conceive and during their early stages of pregnancy of the potential hazards of exposure to these substances, which could alter their children's fertility. It would be interesting to carry out a similar study in women, in order to evaluate whether the impact of endocrine disruptors is the same on the female reproductive system, although this is much more complex to carry out. Since then, the professions exerted by women have greatly evolved, as has the presence of endocrine disruptors in the products used.

SOURCE: Science Daily News, April 2021

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Female Protective Effect !

          Female protective effect clues to sex differences in autism

It is well established that autism occurs much more frequently in boys than in girls, and that girls seem to have a greater resilience to developing the condition. It has been unclear, however, why that is. In a new study, researchers find that autism may develop in different regions of the brain in girls than boys and that girls with autism have a larger number of genetic mutations than boys, suggesting that they require a larger "genetic hit" to develop the disorder. One of the reasons that researchers don't know more about why autism tends to affect boys more frequently than girls is the fact that most studies have been based on male-predominant samples. For this study, the researchers studied a balanced sample of boys and girls ages 8 to 17 including 45 girls and 47 boys with autism, and 45 typically developing girls and 47 typically developing boys. The researchers focused on how the brains of young people with and without ASD process human motion. Children with autism do not pick up on social cues easily, and have difficulty reading reactions. Past studies which relied largely on male subjects found that a part of the brain called the posterior superior temporal sulcus which is thought to be involved in processing auditory and visual stimuli is active in the social perception in typical kids but less responsive for those with ASD. Using a brain imaging technology called functional magnetic resonance imaging, the researchers found that the accepted wisdom that the posterior superior temporal sulcus region constitutes a "neural signature" for autism was primarily true for boys. Genetic analysis allowed the researchers to probe even further into these differences. After examining data from the Simons Simplex Collection a genetic database drawn from more than 2,000 families with at least one child with ASD they again found that there was a larger number of copy number variations containing genes expressed in the same region of the brain the striatum among girls with autism. Researcher said, the findings provide a clue into what is driving the female autism neural profile and may also reveal what drives the "female protective effect.

SOURCE: Science Daily News, April 2021

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Less Anxious Adults !

                                               Childhood diet and exercise creates healthier, less anxious adults

Exercise and a healthy diet in childhood leads to adults with bigger brains and lower levels of anxiety. Though diet and exercise are consistently recommended as ways to promote health, this study is the first to examine the long-lasting, combined effects of both factors when they are experienced early in life. The researchers determined that early life exercise generally reduced anxious behaviors in adults. It also led to an increase in adult muscle and brain mass. The researchers did behavioral analysis, measured aerobic capacity, and levels of several different hormones. One of those they measured, leptin, is produced by fat cells. It helps control body weight by increasing energy expenditure and signaling that less food is required. Early-life exercise increased adult leptin levels. Previously, the research team found that eating too much fat and sugar as a child can alter the microbiome for life, even if they later eat healthier. Together, both studies offer critical opportunities for health interventions in childhood habits. In other words, getting a jump start on health in the early years of life is extremely important, and interventions may be even more critical in the wake of the pandemic. During the COVID-19 lockdowns, particularly in the early months, kids got very little exercise. For many without access to a park or a backyard, school was their only source of physical activity. It is important to find solutions for these kids, possibly including extra attention as they grow into adults. Otherwise they may face physical and mental health issues in the coming decade.

SOURCE: Science Daily News, April 2021

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Products of SQUARE Pharmaceuticals Ltd.

  Product Zolibac TM
  Generic Name Cefazolin
  Strength 1gm
  Dosage form IM/IV Injection
Therapeutic Category Cephalosporin
  Product Cefopen TM
Generic Name



2 gm

Dosage form IM/IV Injection
Therapeutic Category Cephalosporin
  Product Benostar MouthwashTM
  Generic Name Benzydamine Hydrochloride


  Dosage form Mouthwash
  Therapeutic Category NSAID Mouthwash

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