Healthcare online Keeping you up-to-date
VOL.  16     ISSUE:  12  December   2018 Medical Services Department

SQUARE Pharmaceuticals Ltd.





P G Dip. Business Management



Rubyeat Adnan



Dear Doctor,

Welcome to healthcare bulletin "e- SQUARE" !

This time, we have focused on some interesting features like -
Mediterranean Diet !", "Gaming Addiction !", "Exercise Linked BP !", "Skin Pigmentation !",  "Anti-Cancer Drug !", "Delivery Method & Incontinence !".

In our regular feature, we have some products information of SQUARE Pharmaceuticals Ltd. as well.

Please send your feedback !  We always value your comments !

On behalf of the management of SQUARE, we wish you all a very happy, healthy and prosperous life.

Click on to reply mode.

Yours sincerely,


Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals Ltd.

 Mediterranean Diet !  

                                        Statins are more effective for those who follow the Mediterranean Diet

For those who have already had a heart attack or a stroke, the combination of statins and Mediterranean Diet appears to be the most effective choice to reduce the risk of mortality, especially from cardiovascular causes. The traditional Mediterranean diet is rich in fruit, vegetables, legumes, cereals, olive oil, wine in moderation, fish and low in meat and dairy products. Researchers also analyzed the potential underlying mechanisms of this positive interaction, so far poorly explored, between drugs and eating habits. Lead researcher said that the favorable combination of statins and Mediterranean Diet appeared to act, rather than on cholesterol levels, by reducing subclinical inflammation, a condition that predisposes to a higher risk of illness and mortality. This finding is of particular interest especially in the light of our observation that a high level of subclinical inflammation doubled the risk of mortality in patients who already had a heart attack or stroke. Researcherís data suggest that focus should be more on the possible interactions between food and drugs, an aspect largely neglected in epidemiological research. Of course, controlled clinical trials will be needed to clarify these findings. New therapeutic possibilities could be designed for those who have already had a cardiovascular event, allowing a better modulation of the pharmacological intervention in relation to life habits. This is a new aspect of personalized medicine.

SOURCE: HealthDay News, December 2018

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 Gaming Addiction !

                                    Online gaming addiction in men affects brain's impulse control

Internet gaming disorder has become a major public health concern worldwide among both adolescents and young adults. Researchers using functional MRI (fMRI) have found differences in the brains of men and women who are addicted to online gaming. Internet gaming disorder (IGD) is a condition characterized by compulsive playing of online games to the exclusion of other interests. Individuals with IGD often suffer significant impairment or distress and may experience negative effects at work, in school or in relationships because of the amount of time they spend playing. They also show symptoms of withdrawal when not playing. While some evidence exists that IGD is more prevalent among men, there is little existing research on differences in the structure and function of the brains of men and women with the disorder. Men with IGD showed alterations in regional- and network-level brain function. In particular, they had lower brain activity in the superior frontal gyrus, an area of the brain's prefrontal lobe that is important to impulse control. The women with IGD did not exhibit any of these brain alterations. Men have shown lower levels of impulse control in comparison with women, and their impulse control also increases more gradually. A dysfunctional prefrontal cortex specifically in men with IGD may be associated with high impulsivity, a finding partly consistent with those of previous studies of substance addiction. The research adds to a growing body of literature linking the behavioral problems associated with IGD to those found in individuals with substance abuse issues.

SOURCE: HealthDay News, December 2018

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 Exercise Linked BP !

                           Exercise may be as effective as prescribed drugs to lower high blood pressure

Exercise may be as effective as prescribed drugs to lower high blood pressure, suggests a pooled analysis of the available data. But there are no direct head to head comparative trials of exercise and blood pressure lowering drugs, and the numbers of participants in some of the included studies were relatively small, caution the researchers. While promising, the findings shouldn't persuade patients to ditch their blood pressure lowering drugs in favor of an exercise regimen just yet, although patients might want to boost their physical activity levels, advises the lead study author in a linked podcast. Exercise can lower systolic blood pressure -- the amount of pressure in the arteries when the heart is beating and expressed as the top number in any blood pressure reading. But what isn't clear is how exercise compares with blood pressure lowering drugs, of which there are several types, as no direct head to head clinical trials have been carried out. Three sets of analyses were done: all types of exercise compared with all classes of blood pressure lowering drugs; different types of exercise compared with different types of drug; and different intensities of exercise compared with different drug doses. And finally, these analyses were repeated, but in a group of exercise trials that included only participants with high blood pressure, as most of these trials were of young healthy participants with normal blood pressure. The results showed that blood pressure was lower in people treated with drugs than in those following structured exercise programs. Researchers recommend that physicians can start prescribing exercise to their patients, but they also need to be cognizant of the resource implications and ensure that the patients that have been referred to exercise interventions can adhere to them and so really derive benefit.

SOURCE: HealthDay News, December 2018

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Skin Pigmentation !

                                                          Rapid genetic evolution linked to lighter skin pigmentation

Populations of indigenous people in southern Africa carry a gene that causes lighter skin, and scientists have now identified the rapid evolution of this gene in recent human history. The gene that causes lighter skin pigmentation, SLC24A5, was introduced from eastern African to southern African populations just 2,000 years ago. Strong positive selection caused this gene to rise in frequency among some KhoeSan populations. This is a rare example of intense, ongoing adaptation in recent human history and is the first known example of adaptive gene flow at a pigmentation locus in humans- according to the researchers. Individuals who carry two copies of the lighter pigmentation gene are 14 percent lighter-skinned than the population average, the researchers said. The gene SLC24A5 plays a key role in the genetic basis of light skin pigmentation. While light skin is often associated with European ancestry, even in South Africa, the present-day Khoekhoe and San did not experience enough recent migration to account for the frequency of the gene. Rather, strong positive selection during the past 2,000 years was the only way to explain the current distribution. The gene, which is also present in people from the Near East and eastern Africa, was probably initially brought into the region by only a small number of individuals. The actual source of the positive selection is not clear. The researchers theorize that a shift from consuming vitamin D-rich marine animals to consuming pasture animals, or a reduction in exposure to ultraviolent rays, might have changed skin pigmentation over time.

SOURCE: HealthDay News, December 2018

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 Anti-Cancer Drug !

                                 Scientists to produce anti-cancer drugs in yeast

Nature is so complex that natural molecules used for i.e. cancer treatment still can't be produced by chemical synthesis. Today, major chemical and pharmaceutical companies harvest large amounts of rare plants and seeds in order to extract valuable substances. But the production methods based on extracts from natural resources are environmentally damaging and often give rise to extensive piles of chemical waste. In addition, there is a great danger that these rare plants will go extinct. The need to find new and more sustainable production methods for these types of medicines has grown since the UN recently adopted new regulations to protect biodiversity and raw materials in third world countries. In many cases, these very complex plant chemicals can't be synthesized chemically like 'normal' pharmaceuticals -- it simply has to be a bio-catalytic process. The aim of the research project is to provide the pharmaceutical industry with an alternative production route using the cellular workhorse baker's yeast. To start with, the researchers want to map the so-called biosynthetic pathways of the rare plant Rauvolfia serpentina with the common name Indian snakeroot. From traditional Chinese medicine, it is known that Indian snakeroot produces molecules with anticancer effect. However, manufacturing the valuable compounds outside the plant is still not possible, because the biosynthetic pathways are unknown. In short, a biosynthetic pathway is a number of specific genes that code for enzymes, which synthesize a bio-molecule within the cell. Knowing the genetic "route" of the product, makes it possible to move the genes into, for instance, baker's yeast. The goal is to insert the genes into yeast cells that will act as biological cell factories capable of producing large amounts of these specific therapeutic substances.

SOURCE: HealthDay News, December 2018

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 Delivery Method & Incontinence !

                                          Delivery method associated with pelvic floor disorders after childbirth

Vaginal childbirth substantially increases the probability of developing a pelvic floor disorder later in life of a woman. Researchers results of a 10-year study showing that some delivery modes, including spontaneous vaginal delivery, are associated with higher risk of some types of pelvic floor disorders. This study considered a woman's risk of developing one of four pelvic floor disorders: stress urinary incontinence, overactive bladder, anal incontinence and pelvic organ prolapse. The research team enrolled 1,528 women within five to 10 years of their first birth. These women were followed annually for up to nine years. Of the women, 778 delivered all of their children via cesarean birth, 565 had at least one spontaneous vaginal delivery and 185 had at least one delivery involving forceps or vacuum-assistance, also called operative vaginal delivery. The median age at enrollment was 38.3 -- the youngest study participant at enrollment was 22.7 years old and the oldest participant at the end of the study was age 61.7. In all, the researchers found that cesarean delivery substantially reduced the risk of pelvic floor disorders, most notably pelvic organ prolapse, while operative delivery increased the risk. And for pelvic organ prolapse, the magnitude of these differences grew over time. The researchers also found that a large percentage of new cases of urinary and bowel incontinence developed in the first five years after delivery, while pelvic organ prolapse tended to develop many more years after childbirth. A third discovery was that the genital hiatus size is significantly associated with all pelvic floor disorders but most significantly with pelvic organ prolapse. This suggests that the genital hiatus size is a marker that might identify women at high risk of developing pelvic floor disorders with aging.

SOURCE: HealthDay News, December 2018

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New Products of SQUARE Pharmaceuticals Ltd.

  Product PerkinorTM  
  Generic Name Trihexyphenidyl HCl
  Strength 2 mg
  Dosage form Tablet
  Therapeutic Category Antiparkinsons
  Product PerkinorTM
Generic Name

Trihexyphenidyl HCl  

Strength 5 mg
Dosage form Tablet
Therapeutic Category Antiparkinsons
  Product Nebita PlusTM
  Generic Name Nebivolol +Hydrochlorthiazide 
  Strength 5 mg+12.5 mg
  Dosage form Tablet
  Therapeutic Category Antihypertensive

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