Healthcare online Keeping you up-to-date
VOL.  21     ISSUE:  1  January  2023 Medical Services Department

SQUARE Pharmaceuticals Ltd.





P G Dip. Business Management





Mushfiqur Rahman



Dear Doctor,

Happy New Year 2023 !

Welcome to our online healthcare bulletin e- SQUARE !

In this issue, we focused on some interesting features like -
"Liver Damage !
", "IBD Alert !", "Feeling Depressed !", "Obesity & AMD !",  "Oral Insulin !", "Pre-eclampsia Risk !".

In our regular feature, we have some products information of SQUARE Pharmaceuticals Ltd. as well.

Please send your feedback !  We always value your comments !

Click on to reply mode.

On behalf of the management of SQUARE, we wish you all a very happy, healthy and prosperous life.


Yours sincerely,


Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals Ltd.

 Liver Damage !

Fast-Food Fans May Face Liver Damage

The study found that eating at least 20% of total daily calories from fast food can increase the risk of nonalcoholic fatty liver disease, a potentially life-threatening condition where fat builds up in the liver. The disease can lead to cirrhosis and its complications, including liver failure and liver cancer. People with obesity or diabetes are more vulnerable to the harmful effects of fast food on the liver, although the general population is not immune to the harm. Lead investigator at the University of Southern California hoped that this study would encourage people to seek out more nutritious, healthy food options. The researchers analyzed data on diet and fatty liver measurements for nearly 4,000 adults. Nearly 30% of them got 20% or more of their total daily calories from fast food, such as burgers, fries, pizza, and the like. They found that people with obesity or diabetes who take in one-fifth or more of their daily calories from fast food had severely high levels of fat in their liver, compared with those who eat less or no fast food. The general population had moderate increases in liver fat when one-fifth or more of their diet was made up of fast food. The findings are particularly “alarming” given the increase in fast-food consumption over the past 50 years, regardless of socioeconomic status, the researcher added.
For people who have limited options and need to eat fast food, there are healthy choices at most restaurants; they just need to be smart about reading labels, watching calories, and ordering the healthier options, added the researcher at Rush University Medical Center in Chicago.

SOURCE: WebMD Health News, January 2023

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 IBD Alert !

                              Inflammatory Bowel Disease (IBD): Frequent Antibiotic Use May Increase Risk

Frequent use of antibiotics in people over the age of 40 could increase the risk of developing inflammatory bowel disease (IBD), according to a study published today in the online journal Gut. Researchers used medical data from Danish citizens ages 10 and up who were not diagnosed with IBD at the start of the study period. More than 6 million people were included. More than 5.5 million were prescribed antibiotics at least once during the study period, which lasted from 2000 to 2018. There were 36,017 new diagnoses of ulcerative colitis and 16,881 of Chron’s disease, both of which fall under the IBD umbrella.
The researchers said they found that compared to people with no antibiotic use, people who took at least one round of antibiotics were more likely to develop IBD, regardless of age. However, older age was associated with a higher risk.
The researchers also found that the risk factor for developing IBD was cumulative and subsequent antibiotic courses increased the risk by 11%, 15%, and 14%, respectively.
The increased risk rose even higher for people who took at least five rounds of antibiotics:
• For ages 10 to 40, there was a 59% higher risk
• For ages 40 to 60, the risk doubled
• For people over 60, there was a 95% increased risk
The study noted that the highest risk of developing IBD occurs one to two years after antibiotic use. The risk decreases each subsequent year without antibiotic use.
• For people 10 to 40, the risk was 40% higher for the first two years and then dropped to 13% four to five years later with no further antibiotic use
• For people 40 to 60, the initial risk was 66% higher for the first two years and then dropped to 21% four to five years later with no further antibiotic use
• For people over 60, initially, the risk was 63% higher and that dropped to 22% four to five years later when there was no further antibiotic use
Experts point out antibiotics are essential in certain incidents, but their use should take into account the inflammatory bowel disease risk.

SOURCE: Healthline, January 2023

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 Feeling Depressed !

                                          Performing Acts of Kindness May Help

The study found that performing acts of kindness led to improvements not seen in two other therapeutic techniques used to treat depression or anxiety. Researcher said that the acts of kindness technique was the only intervention tested that helped people feel more connected to others. Doing nice things for people and focusing on the needs of others may actually help people with depression and anxiety feel better.
The study involved 122 people in central Ohio who had moderate to severe symptoms of depression, anxiety, and stress. After an introductory session, the participants were split into three groups. Two of the groups were assigned to techniques often used in cognitive behavioral therapy (CBT) for depression: planning social activities or cognitive reappraisal. The social activities group was instructed to plan social activities for two days a week. Another group was instructed in one of the staples of CBT: cognitive reappraisal. These participants kept records for at least two days each week that helped them identify negative thought patterns and revise their thoughts in a way that could reduce depression and anxiety. Members of the third group were instructed to perform three acts of kindness a day for two days out of the week. Acts of kindness were defined as "big or small acts that benefit others or make others happy. Participants followed their instructions for five weeks. The findings showed that participants in all three groups showed an increase in life satisfaction and a reduction of depression and anxiety symptoms after the 5 weeks of the study. These results are encouraging because they suggest that all three study interventions are effective at reducing distress and improving satisfaction. But acts of kindness still showed an advantage over both social activities and cognitive reappraisal by making people feel more connected to other people, which is an important part of well-being. In addition, the acts of kindness group showed greater improvements than the cognitive reappraisal group for life satisfaction and symptoms of depression and anxiety. So beyond traditional CBT, acts of kindness may have additional benefits in creating social connections.

SOURCE: Science Daily, January 2023

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 Obesity & AMD !

                            Obesity Lead to Macular Degeneration

A recent researcher has showed that life stressors such as obesity reprogram immune system cells and make them destructive to the eye as it ages.
Age-related macular degeneration (AMD) is a major cause of irreversible blindness worldwide and affected approximately 196 million people in 2020. It comes in two forms:
• Dry AMD, characterized by the accumulation of fatty deposits at the back of the eye and the death of nerve cells in the eye,
• Wet AMD, which is characterized by diseased blood vessels that develop in the most sensitive part of the sight-generating tissue, called the macula.
It is already known that the immune system in the eye of a person with AMD becomes dysregulated and aggressive. Normally, immune cells keep the eye healthy, but contact with pathogens such as bacteria and viruses can make them go away.At the same time, immune cells are also activated when the body is exposed to stressors such as excess fat in obesity, making being overweight the number one non-genetic risk factor for developing AMD, after smoking.
In their study, they used obesity as a model to accelerate and exaggerate the stressors experienced by the body throughout life. They found that transient obesity or a history of obesity leads to persistent changes in the DNA architecture within immune cells, making them more susceptible to producing inflammatory molecules. The researchers hope their discovery will lead other scientists to broaden their interest beyond obesity-related diseases to other diseases characterized by increased neuro inflammation, including Alzheimer's disease and multiple sclerosis.

SOURCE: Science Daily, January 2023

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 Oral Insulin !

                    Another Step Toward an Insulin Tablet

Patients with diabetes have trouble regulating their blood glucose levels because they produce little or no insulin. Synthetic insulin has existed for over a hundred years, but it is often administered with an injection or an implanted pump. People affected by diabetes often take insulin multiple times per day, so frequent injections can be painful, and as a result, some patients do not take the recommended dose at the correct times.
An oral form of the drug would be ideal, but the harsh environment of the stomach breaks down and neutralizes the hormone before it can be absorbed by the intestines and get into the bloodstream. Previous attempts at oral administration protected the hormone from stomach acids but relied on insulin to passively diffuse into the cells that line the colon, which isn't very efficient.
To make these tablets, the researchers covered magnesium micro particles with a layer of an insulin-containing solution and a layer of liposomes. They then mixed these particles with baking soda, pressed them into mini-tablets that were about 3 mm long then covered them with an esterified starch solution. The starch protected the tablets from stomach acid, allowing them to reach the colon intact. As they broke down, the magnesium micro particles reacted with water to generate a stream of hydrogen gas bubbles, which acted as micro motors that propelled insulin toward the colon's lining to be absorbed. The researchers also tested their mini-tablets in animals and found that they could significantly reduce the animals' blood glucose levels for over five hours. In fact, they could maintain a glucose level almost as low as injection-delivered insulin. Though more work is needed, the researchers say that this is a concrete step toward creating more oral formulations of traditionally injection-only medications.

SOURCE: Science Daily, January 2023

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Pre-eclampsia Risk !

Mediterranean Diet Lead to Lower Pre-eclampsia Risk

In a new study evaluating the Mediterranean diet and adverse pregnancy outcomes, found that women who conceived while adhering to the anti-inflammatory diet had a significantly lower risk of developing preeclampsia during pregnancy. The researchers found the association was stronger in women who are traditionally considered to be of advanced maternal age, those 35 or older.
Preeclampsia is a serious blood pressure condition that develops during pregnancy and puts stress on the mother's heart. Left untreated, the condition can cause serious complications like weakened kidney and liver function and decreased blood supply to the fetus. In addition to preeclampsia, the risk of gestational diabetes also decreased in women who more closely followed the heart-healthy diet. The study focused on the women's eating habits during the three months prior to their visit and asked the participants to report their intake of common foods and beverages. Individuals' responses were then categorized into the nine components of a Mediterranean diet -- vegetables, fruits, nuts, whole grains, legumes. The data was compiled, analyzed and studied by researchers and showed:
• Of the 7,798 women enrolled, 10% were 35 years old or older, 11% were non-Hispanic Black, 17% were Hispanic, and 4% were Asian.
• 20% of enrollees had obesity at the onset of their participation.
• A high Mediterranean diet score was related to 21% lower odds of having any adverse pregnancy outcome, as well as a 28% and 37% lower risk of having preeclampsia/eclampsia and gestational diabetes.
The researchers also looked at the individual components of the Mediterranean diet and found higher intakes of vegetables, legumes and fish were related to lower associated risk of an adverse pregnancy. These findings uniquely demonstrate that adoption of a Mediterranean diet pattern may represent an important lifestyle approach for the prevention of adverse pregnancy outcomes. These findings add to the growing body of evidence demonstrating that the Mediterranean-style diet may play an important role in preserving the health of women across the lifespan, including during pregnancy.

SOURCE: Science Daily, January 2023

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Products of SQUARE Pharmaceuticals Ltd.

Product AntiscarTM
  Generic Name Extractum Cepae +Heparin +Allantoin
  Strength 100 mg+ 0.278 mg+10 mg
  Dosage form Gel
  Therapeutic Category Antiscar
  Product Nomi TM
Generic Name


Strength 2.5 mg/spray
Dosage form Nasal Spray
Therapeutic Category Antimigraine
Product MagnideTM
Generic Name Magnesium Oxide
  Strength 365 mg
Dosage form Tablet
  Therapeutic Category Mineral

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