Healthcare online Keeping you up-to-date
VOL.  14     ISSUE:  7    July 2016 Medical Services Department

SQUARE Pharmaceuticals Ltd.





P G Dip. Business Management





Dear Doctor,

Welcome to online bulletin 'e-SQUARE'.

Our current issue focused on some interesting features like -
Alzheimer & Pain !", "IVF & Cancer !", "New Treatment !", "Red Meat Alert !",  "Statin Lower Ca !", "Women At Risk !".

In our regular feature, we have some products information of SQUARE Pharmaceuticals Ltd. as well.

We will appreciate your feedback !

Click on to reply mode.

Yours sincerely,


Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals Ltd.

 Alzheimer & Pain !

                                                                          Alzheimer's May Hamper Ability to Perceive Pain

Alzheimer's disease may affect people's ability to recognize when they are in pain, a new study shows. Undetected pain may allow underlying health issues to go untreated, leading to serious complications, such as organ damage, researchers cautioned. For the three-year study, the researchers tested two groups of adults who were aged 65 or older. One group was made up of people diagnosed with Alzheimer's disease, which affects thinking skills, memory and intellect. Members of the second group did not have the progressive neurological disease. The study used a device to subject participants to different heat sensations and asked them to report their pain levels. After the tests, the researchers analyzed self-reported pain. "We found that participants with Alzheimer's disease required higher temperatures to report sensing warmth, mild pain and moderate pain than the other participants," said study first author. "What we didn't find was a difference between the two groups in reporting how unpleasant the sensations were at any level." Participants with Alzheimer's were less able to recognize when they were in pain, but their pain tolerance was not diminished, the study found. "While we found that their ability to detect pain was reduced, we found no evidence that people with Alzheimer's disease are less distressed by pain nor that pain becomes less unpleasant as their disease worsens," study author said. More studies are needed to explore pain perception among those with Alzheimer's disease, the researchers said. They added that doctors should use a variety of methods to evaluate patients' level of discomfort, including pain scales, behavioral changes and nonverbal cues, like facial expressions. This is particularly important once Alzheimer's patients begin having problems with verbal communication, the study authors said. "As people age, the risk of developing pain increases, and as the population of older adults continues to grow, so will the number of people diagnosed with Alzheimer's disease," researcher added. "We need to find ways to improve pain care in people with all forms of dementia and help alleviate unnecessary suffering in this highly vulnerable population." The study findings were published recently in the journal BMC Medicine. 

SOURCE: HealthDay News, July 2016.

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 IVF & Cancer !

                                                                                           IVF Won't Raise Risk for Breast Cancer

Women who undergo in vitro fertilization (IVF) to boost their odds of having a baby aren't at increased risk of breast cancer, according to Dutch researchers. Their study of more than 25,000 women found no "significant increase in the long-term risk of breast cancer among women treated with these IVF regimens." A fertility expert believes the findings will ease patients' concerns. "As the number of women undergoing IVF continues to increase, it's reassuring that we do not subject them to an increased risk of breast cancer," - chief of the Center for Human Reproduction at North Shore University Hospital in Manhasset, N.Y. said. According to the Dutch research team, prior data has hinted that that certain hormones, including estrogens and progestogens, can affect breast cancer risk. IVF procedures do cause levels of certain of these hormones to drop temporarily, while others may surge. For this reason, experts have speculated that IVF could affect women's risk for breast cancer. To help settle the matter, researchers followed more than 19,000 women who underwent IVF between 1983 and 1995. The women averaged 33 years of age when the study began, and underwent an average of between three and four IVF cycles. By the time the women had reached age 54, research team compared their breast cancer rates to that of nearly 6,000 other women of similar age who had not undergone IVF. The risk for breast cancer among the women who had IVF was similar to the risk of women who didn't have IVF, the team reported July 19 in the Journal of the American Medical Association. The cumulative rate of breast cancer was 3 percent for the IVF group, compared to 2.9 percent for the non-IVF group, the study showed. The study's authors also found that the type of fertility drugs the women received had no effect on their risk for breast cancer. Interestingly, women who had seven or more IVF cycles actually had a much lower risk for breast cancer than those underwent just one or two rounds of the treatment. "Since we now believe that it takes years for a clinically detectable cancer to develop, short exposure [usually about two weeks] to high estrogen levels in IVF should not make a difference in the natural history of breast cancer," an expert from the Center for Human Reproduction at North Shore University Hospital in Manhasset, N.Y. said explained. A breast cancer expert and chief of surgical oncology at Lenox Hill Hospital in New York City said, "The question as to whether or not IVF increases the risk for future breast cancer is often asked, especially as more women are delaying pregnancy and IVF is becoming a very common occurrence." While the study results are encouraging, she believes that they "need to be validated with studies designed to look at the relationship of breast cancer risk in women receiving the hormones for IVF. "For now, the information is helpful to women trying to weigh the risks and benefits of IVF," she added. "Women at a high risk for breast cancer may still need to be cautious about IVF and the high doses of hormones that are used."

SOURCE: HealthDay News, July 2016.

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 New Treatment !

New Treatments Helping Kids With Juvenile Arthritis

New treatments for juvenile arthritis offer hope to children with the chronic autoimmune condition, doctors say. Scientists are still working to understand what causes juvenile arthritis and how to stop its progression. But, kids coping with its effects have reason to be optimistic, according to a rheumatologist and clinical team leader at the U.S. Food and Drug Administration. "We don't have a cure for juvenile arthritis -- we're not there yet," he said in an FDA news release. "But we're making progress." But it's important to note that the drugs aren't risk-free. Juvenile arthritis is one of the most common chronic childhood conditions, affecting nearly 300,000 children in the United States, according to the FDA. The disease causes the immune system to attack its own tissues, resulting in pain, swelling, tenderness and stiffness in the joints. These symptoms usually begin before children are 16 years old. There are several types of juvenile arthritis, known collectively as Juvenile Idiopathic Arthritis (JIA). JIA can involve the knees, wrists and ankles as well as smaller joints, according to the FDA. The largest subtype of JIA is known as polyarticular JIA, which affects many joints. Systemic JIA is another subtype that affects the entire body, triggering fevers and rashes, the agency explained. New treatments can help. In the past, children with the condition were given drugs to suppress their immune system or medications to ease inflammation, including aspirin and ibuprofen. More recently, however, drugs extracted from biological sources -- called biologics -- have become available to treat polyarticular and systemic JIA. Different biologics tend to work better for different subtypes of the disease, he said. Among the biologics approved by the FDA since 1999 for treatment of polyarticular JIA are Adalimumab; Abatacept; Etanercept; and Tocilizumab. Biologics approved since 2011 for treatment of systemic JIA are Tocilizumab and Canakinumab. These medications are typically injected under the skin or given intravenously. Children usually take them for years. The treatments target specific molecules in the body that trigger inflammation called cytokines, and other naturally occurring proteins that stimulate the immune system, according to team leader. But biologics are powerful drugs that suppress the immune system and can increase children's risk of serious infections, including tuberculosis. The FDA weighs these risks and whether the potential benefits of the drugs for children with juvenile arthritis outweigh them, he added. "It's possible that safety issues might come up in kids that we have not found in adults," he said. "For example, these drugs may affect the developing body and immune system in children, and that may warrant changes in the labels to let both health care providers and patients know what are the risks involved, and how to recognize and respond to potential problems."

SOURCE: HealthDay News, July 2016.

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 Red Meat Alert !

                                                              Too Much Red Meat Might Harm Kidneys, Study Suggests

Eating red meat may boost the risk for kidney failure, but swapping even one daily serving of red meat for another protein may reduce the risk, a large study from Singapore suggests. Red meat intake -- in this case, mostly pork -- was strongly associated with an increased risk of end-stage renal disease, the loss of normal kidney function. The relationship was also "dose dependent" -- meaning the higher the consumption, the greater the risk. The association held up even after compensating for factors that could skew the results, such as lifestyle and other health conditions, the study authors noted. "Our findings suggest that patients with chronic kidney disease or the general population worried about their kidney health can still maintain protein intake but consider switching to plant-based sources," study author said. "However, if they still choose to eat meat, fish/shellfish and poultry are better alternatives to red meat," study author noted. The study adds new data to a conflicting body of evidence on the relationship between protein intake, particularly red meat, and kidney disease, experts noted. About 20 million Americans have chronic kidney disease, according to the U.S. Centers for Disease Control and Prevention. Between 2000 and 2008, the number of new cases among people 65 and older more than doubled, says the U.S. National Institute of Diabetes and Digestive and Kidney Diseases. And while new cases have leveled off, recent data from a federal registry show the number of people requiring kidney dialysis continues to rise. Red meat has been implicated in recent reports and studies as potentially harmful to human health. The World Health Organization last year warned of a possible link between red meat and cancer. And a November 2015 study in the journal Cancer found that meat cooked at high temperatures could potentially affect kidney cancer risk. For the new study, researchers followed more than 63,000 Chinese adults in Singapore for an average of 15.5 years. Food questionnaires were used to gather data on people's daily protein consumption. Records on the incidence of end-stage renal disease came from a nationwide renal registry. Ninety-seven percent of red meat intake in the study population consisted of pork. Other protein sources included poultry, fish/shellfish, eggs, dairy products, soy and legumes. People consuming the highest amounts of red meat had a 40 percent increased risk of developing end-stage kidney disease, compared with people who ate the lowest amounts, the study found. No association was found with poultry, fish, eggs or dairy products, while soy and legumes appeared to be slightly protective. The study also found that replacing one serving of red meat with another protein reduced the risk of kidney failure -- up to 62 percent for poultry. The study, published July 14 in the Journal of the American Society of Nephrology, was supported by funding from the U.S. National Institutes of Health.

SOURCE: HealthDay News, July 2016.

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 Statin Lower Ca !

                                                                            Statin Treatment Linked to Fewer Cancer Deaths

Being treated for high cholesterol with statins is being linked with a reduced risk of death and better survival from four common cancers(Ca), a medical conference has heard. The results come from a study of 14 years of UK data that included nearly a million people. High cholesterol is known to increase the risk of heart disease, but less is known about the effect on the risk of developing cancer. Previous research in animals found that giving statins for high cholesterol can reduce the risk of breast cancer, and researchers wanted to see if there was any effect of high cholesterol and its treatment on cancer deaths. Anonymous information on people diagnosed for the first time with lung cancer, breast cancer, prostate cancer and bowel cancer was gathered from hospitals between January 2000 and March 2013. When researchers from several UK centres analysed the data, they found that people diagnosed with high cholesterol and one of the four cancers were less likely to die from cancer. However, being diagnosed with high cholesterol usually lead to treatment, often with statins. So the researchers think the statin treatment might explain the protective effect, rather than high cholesterol itself. They adjusted for other risk factors, such as age, gender, ethnicity, and other common causes of death. Having a diagnosis of high cholesterol was linked to a:
22% lower risk of death in lung cancer
43% lower risk of death in breast cancer
47% lower risk of death in prostate cancer
30% lower risk of death in bowel cancer.
The study could only find a link between high cholesterol and a lower death risk, rather than establishing any cause-and-effect. However, high cholesterol has previously been linked with an increased risk of cancer, whereas animal experiments suggest that lowering cholesterol with statins may reduce it. The findings were presented to the European Society of Cardiology Frontiers in CardioVascular Biology conference in Florence, Italy. In a statement, lead author says: "The discovery of a link between obesity and high cholesterol as risk factors for cancer has been exciting for researchers and the public. "Even trendier is the idea that if high cholesterol can cause cancer, then cholesterol lowering interventions such as statins could reduce this risk." He continues: "Our research suggests that there's something about having a high cholesterol diagnosis that improves survival and the extent to which it did that was quite striking in the four cancers studied. Based on previous research we think there's a very strong possibility that statins are producing this effect." He believes these findings are also likely to be seen in other cancers, "but this is only speculation and would need to be confirmed by studies in different types of cancer." Senior author it is possible other medications taken for heart-related conditions may also help with cancer survival. "Other cardiovascular medications may also be protective and explain the varying levels of risk reduction in the four cancer types. For example, prostate cancer is associated with heart disease and these patients tend to take ACE inhibitors and beta-blockers," he says. However, he cautions it is too soon to recommend statins alongside cancer treatment without a formal trial: "Patients with cancer who are at high risk or have established cardiovascular disease should be given statins as per current guidelines. I don't think at the moment we can give statins for cancer per se. But this could change if there was a positive result in the clinical trial."

SOURCE: European Society of Cardiology, July 2016.

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 Women At Risk !

Women Smokers at Higher Risk for Brain Bleed

Strokes characterized by bleeding inside the lining of the brain are more common among smokers, especially women, researchers report. These serious strokes -- called subarachnoid hemorrhages -- are eight times more common among women who smoke more than a pack a day compared to nonsmokers, Finnish researchers found. They're three times more common among men who smoke the same amount. Even light smoking tripled a woman's risk for this type of stroke, the study found. "There is no safe level of smoking, and naturally, the best option is never to start," lead researcher said. "The message for policymakers is that by implementing effective strategies against smoking, they can considerably reduce the burden of subarachnoid hemorrhage," researcher noted. For the study, they collected data on nearly 66,000 adults listed in Finnish national surveys since 1972. Participants were followed for an average of 21 years, until they had a first stroke, died, or until the end of 2011. The researchers found that among light smokers -- one to 10 cigarettes a day -- women were three times more likely to have subarachnoid hemorrhage, and men were twice as likely to have one compared to nonsmokers. Among those who smoked 11 to 20 cigarettes a day, women were four times more likely and men two times more likely to suffer this type of stroke, the investigators found. But those who quit smoking significantly reduced their odds of having a subarachnoid hemorrhage. After six months without smoking, their risk fell to the level of nonsmokers, the researchers reported. Although subarachnoid hemorrhage is more common among women than men, the reasons why are unclear, researcher said. Lead researcher believes the elevated risk in women largely comes down to the harms of smoking. Study author said that heavy-smoking females with unruptured aneurysms in their brain are a high-risk population, and their aneurysms should be treated. The report was published online July 21 in the journal Stroke.

SOURCE: HealthDay News, July 2016.

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 Products of SQUARE Pharmaceuticals Ltd.

  Product Fusitop-HC
  Generic Name Fusidic Acid+Hydrocortisone
  Strength 2%+1% 
  Dosage form Cream
  Therapeutic Category Topical Corticosteroid Combination
  Product Redclov   
Generic Name

Redclover Isoflavone

Strength 40 mg
Dosage form Capsule
Therapeutic Category Hormone (Natural Estrogen)
  Product Gol
  Generic Name Macrogol+Nacl+KCl+NaHCO3
  Strength 13.125gm+350.7mg+46.6mg+178.5 mg
  Dosage form Oral Solution
  Therapeutic Category Laxative

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