Healthcare online Keeping you up-to-date
VOL. 15  ISSUE:  4  April  2017 Medical Services Department

SQUARE Pharmaceuticals Ltd.





P G Dip. Business Management








Dear Doctor,

Welcome to our healthcare bulletin 'e-SQUARE'.

Our current issue focused on some interesting features like -

"Antibiotic Alert !", "Breast Cancer Risk !", "Fitness Linked Stroke !", "Insomnia Risk !,  "Race Linked Teens' BP !", "Virus Linked Celiac Disease !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals Ltd. as well.

We will appreciate your feedback !

Click on to reply mode.

Yours sincerely,


Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals Ltd.

 Antibiotic Alert !

                                              Prolonged Antibiotic Use Tied to Precancerous Colon Growths

Taking antibiotics for an extended period in early to middle adulthood might increase risk for precancerous growths in colon, a large study suggests. Women who took antibiotics for two weeks or more in their 20s through their 50s were more likely to have colon lesions in their 60s than women who didn't take the drugs for an extended period, researchers found. If not removed, these lesions -- called polyps or adenomas -- can lead to colon cancer. "This suggests that alterations in the naturally occurring bacteria that live in one's intestines caused by antibiotics might predispose individuals to colorectal cancer," lead researcher said. But, although the risk for colon cancer was raised, it wasn't to a level "where it should worry individuals who need to take antibiotics for clear medical reasons," he said. He also cautioned that this study cannot prove that long-term antibiotic use was the cause of the polyps, only that the two seem to be associated. And, though the study was limited to women, the link likely also holds true for men, he added. "More research needs to be done to understand the interaction between alterations in one's gut bacteria and future risk of colorectal cancer," he said. Antibiotics disrupt the diversity and number of bacteria in the gut, or "microbiome." They also reduce resistance to toxic bacteria. All of this might play a role in the development of precancerous growths, he said. In addition, bacteria that require antibiotics may cause inflammation, which is a known risk for colon cancer, he added. For the report, researchers collected data on more than 16,600 women 60 and older who took part in the Nurses Health Study. The women provided a history of antibiotic use between ages 20 and 59. They also had had at least one colonoscopy between 2004 and 2010. Nearly 1,200 precancerous polyps in the colon were found during that time. Use of antibiotics within the previous four years wasn't associated with a heightened risk of polyps, but long-term use in the past was, he said. For example, two months of antibiotic use in her 20s or 30s upped a woman's odds for polyps 36 percent compared to those who didn't the drugs for a prolonged period. The risk rose further when the extended medication use occurred in one's 40s or 50s, researchers found. Shorter-term use wasn't without risk, either. Taking antibiotics for more than 15 days between ages 20 and 59 also increased the chances of finding polyps, the study found. Research team acknowledged the study had limitations. For one, there was no information on the types of antibiotics used. Also, it's possible that some growths existed before antibiotics were taken, the researchers said. The report was published online April 4 in the medical journal Gut.   

SOURCE: HealthDay News, April 2017

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 Breast Cancer Risk !

                        More Asian-American Women Getting Breast Cancer

Breast cancer rates among Asian-Americans are steadily rising in contrast to other racial/ethnic groups, a new study suggests. Researchers from the Cancer Prevention Institute of California reviewed data from 1988 to 2013 on breast cancer among women in California from seven Asian ethnic groups. These included Chinese, Japanese, Koreans, Filipinos, Vietnamese, South Asians (Asian Indians and Pakistanis), and Southeast Asians (Cambodians, Laotians, Hmong, Thai). During the study period, all of these groups -- except Japanese women -- had an overall increase in breast cancer incidence. The largest increases were among Koreans, South Asians and Southeast Asians, the study authors said. "These patterns warrant additional attention to public health prioritization to target disparities in access to care, as well as further research in identifying relevant breast cancer risk factors for specific breast cancer subtypes," lead researchersaid. Among women over age 50, there were increases in all Asian-American ethnic groups. In women under 50, there were large increases among Vietnamese and other Southeast Asian groups. Breast cancer rates among Asian-American women as a whole were lower than among white women. But the rates among Japanese and Filipino women younger than 50 were similar to rates for white women of the same age. The researchers also found that HER2 breast cancer was more common among Korean, Filipino, Vietnamese and Chinese women than among white women. HER2 (human epidermal growth factor receptor 2) is a gene that plays a role in the development of breast cancer. The study authors noted this type of cancer tends to grow more quickly and spread more aggressively. Lead researcher suggested that future research into breast cancer risk factors in Asian women might look at early life exposures and possible genetic susceptibility. The study was published in the journal Breast Cancer Research and Treatment. 

SOURCE:  HealthDay News, April 2017

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Fitness Linked Stroke !

                                                    Fitness, Not Fat, Is Key to Post-Stroke Recovery

People who were active and exercised regularly before their stroke were less likely to face disability after the attack, researchers say. But the amount of body fat a person had did not seem to be tied to post-stroke disability, the study found. Fitness was key, though. "Being physically inactive before stroke predicts a higher risk of being dependent both before and after stroke," study author said. Her team's findings were published online April 5 in the journal Neurology. The new study involved more than 18,000 people with no history of stroke who were followed for an average of 12 years. During that time, nearly 1,400 of the participants suffered a stroke but survived. Three years after their stroke, those who had exercised regularly before their stroke were 18 percent more likely to be able to perform basic tasks -- such as bathing on their own, the researchers found. The fitter individuals were also 16 percent more likely to be able to perform more complex tasks, such as managing money on their own, compared to those who did not exercise before their stroke, the findings showed. "We also found that a person's body mass index was not a factor in predicting their level of disability after stroke," she said in a journal news release. Body mass index is an estimate of body fat based on weight and height.

SOURCE: HealthDay News, April 2017

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 Insomnia Risk !

                               Sleepless Nights, Unhealthy Hearts?

More worrisome news for people who toss and turn all night: Insomnia appears to be linked to a heightened risk for heart attack or stroke, a research review from China suggests. "We found that difficulty initiating sleep, difficulty maintaining sleep, or non-restorative sleep were associated with 27 percent, 11 percent, and 18 percent higher risks of cardiovascular and stroke events, respectively," study co-author said. The reasons why aren't fully understood, she said. However, the study doesn't establish a cause-and-effect relationship. Sleep specialists say millions of Americans get too little sleep. "In modern society, more and more people complain of insomnia." she added. Evidence of insomnia's harmful effects on overall health has accumulated in recent years. "Previous studies have shown that insomnia may change metabolism and endocrine function, increase [nervous system] activation, raise blood pressure," she said. It also can spark a rise in levels of certain inflammation-related proteins. All of these are risk factors for heart disease and stroke, she explained. For this report, the investigators looked at 15 studies that enlisted nearly 161,000 participants in all. The studies variously explored potential links between insomnia and a range of heart disease concerns, including heart attack, stroke and heart failure. The association between insomnia and heart attack and stroke risk might even be slightly stronger among women. But that finding did not reach "statistical significance," Research team said in a news release from the European Society of Cardiology. "However, we do know that women are more prone to insomnia because of differences in genetics, sex hormones, stress, and reaction to stress," she said. "It may therefore be prudent to pay more attention to women's sleep health." She added that "health education is needed to increase public awareness of insomnia symptoms and the potential risks, so that people with sleep problems are encouraged to seek help." The findings were published in the March 31 issue of the European Journal of Preventive Cardiology.

SOURCE: HealthDay News, April 2017

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 Race Linked Teens' BP !

                                                         Race May Play Role in Obese Teens' Blood Pressure

Obese teenagers are at increased risk of high blood pressure, but the effects of those extra pounds may vary by race and ethnicity, a new study suggests. Researchers found that obesity had a bigger impact on blood pressure of Hispanic and white teens, compared to their black and Asian peers. It appeared to raise their risk of high blood pressure by four to six times. Pediatric experts said the impact on Hispanic teenagers was striking. Normal-weight Hispanic kids had a low rate of high blood pressure, at just over 1 percent. That shot up to nearly 8 percent among those who were obese. High blood pressure at a young age can set the stage for serious health problems in adulthood, including stroke and heart disease. All children should have their blood pressure checked at routine doctor visits, starting at age 3, the senior researcher on the study said. Doctors should also be aware that obesity can have a particularly strong effect on Hispanic kids' blood pressure, study author said. Doctors have known for years that obese kids are at increased risk of high blood pressure, researcher noted. But the role of race and ethnicity has been unclear, he added. So research team studied a diverse group of more than 21,000 Houston adolescents who had their blood pressure screened at school. Overall, almost 3 percent were diagnosed with high blood pressure -- after showing persistently high readings at three screenings. Hispanic kids had the highest rate, at just over 3 percent. They also had the highest obesity rate, at 23 percent, the findings showed. At the other end of the spectrum, Asians had the lowest rates of high blood pressure (1.7 percent) and obesity (10 percent). In general, the study found, excess weight was linked to a raised risk of high blood pressure across all racial and ethnic groups. But the impact of obesity was most clear among Hispanic and white kids: It raised their risk nearly sixfold and fourfold, respectively, compared to normal-weight students. Weight-related differences were smaller among black and Asian students, the researchers said. Among black teens, 2 percent of those with a normal weight had high blood pressure, versus 4.5 percent of obese teens. It's not clear why obesity affected kids differently, and the study only points to an association, not a direct cause-and-effect relationship. For parents, though, the bottom line is fairly straightforward, researcher added. Be aware that kids can have high blood pressure, and that extra pounds are a risk factor. If teenager's blood pressure has not been checked in a while, it should be, Samuels said. "Once kids move on to college, then young adulthood, they may stop going to the doctor," he noted. "Ideally, we want to catch high blood pressure when they're teenagers." Research team reported the findings online April 10 in Pediatrics. 

SOURCE: HealthDay News, April 2017

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 Virus Linked Celiac Disease !

                                                          Surprising Culprit Behind Celiac Disease?

A typically harmless type of virus might sometimes trigger celiac disease, a new study suggests. Celiac disease is caused by an abnormal immune response to the protein gluten, which is found in wheat, rye and barley. The condition damages the lining of the small intestine, and the only effective treatment is a gluten-free diet. This new study found that when mice were infected with particular strains of a common human intestinal reovirus, their immune system could not tolerate gluten. Patients with celiac disease also had much higher levels of antibodies against reoviruses than those without the autoimmune disease, the researchers said. "This study clearly shows that a virus that is not clinically symptomatic can still do bad things to the immune system and set the stage for an autoimmune disorder, and for celiac disease in particular," senior study author said. However, the specific virus and its genes, the interaction between the microbe and the host, and the health status of the host are all going to matter as well," she added . The researchers said the findings provide further evidence that viruses may play a role in the development of autoimmune disorders such as celiac disease and type 1 diabetes, and they suggest that vaccines might help prevent such diseases. "During the first year of life, the immune system is still maturing, so for a child with a particular genetic background, getting a particular virus at that time can leave a kind of scar that then has long-term consequences," she said. "That's why we believe that once we have more studies, we may want to think about whether children at high risk of developing celiac disease should be vaccinated," she added.

SOURCE: HealthDay News, April 2017

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New Products of SQUARE Pharmaceuticals Ltd.

  Product InfudexTM 5 IV Infusion 1000 ml
  Generic Name Dextrose Anhydrous
  Strength 5% W/V
  Dosage form Pareteral
Therapeutic Category Parenteral Nutrition
  Product InfudexTM 10 IV Infusion 1000 ml
Generic Name

Dextrose Anhydrous


10% W/V

Dosage form Pareteral
Therapeutic Category Hormone Replacement Therapy
  Product InfudexTM 5 IV Infusion 500 ml
  Generic Name Rextrose Anhydrous

5% W/V

  Dosage form Pareteral
  Therapeutic Category Parenteral Nutrition

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