Healthcare online Keeping you up-to-date
VOL.  10     ISSUE:  8    August  2012 Medical Services Department

SQUARE Pharmaceuticals Ltd.





P G Dip. Business Management

A. S. M. Shawkat Ali

MBBS, M. Phil





Dear Doctor,

Welcome to this edition of 'e-SQUARE'.

Our current issue focused on some interesting features like -
Poor Sleep !", ""ADHD" !", "Prostate Cancer !", "Night-Time Cough !",  "Hypothermia !", "Kidney Stone !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals Ltd. as well.

We will appreciate your feedback !

Click on to reply mode.

Yours sincerely,


Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals Ltd.

 Poor Sleep !

 Poor Sleep Hampers Vaccine Effectiveness: Study

Lack of sleep can reduce the effectiveness of vaccinations, according to a new study. Researchers measured the sleep patterns of 125 adults who received the three-shot course of the vaccine to protect against hepatitis B. The immune systems of participants who slept less produced fewer antibodies in response to the vaccine and blood tests showed that they did not meet the standard of protection from the virus. People who slept less than six hours per night were nearly 12 times more likely to be left unprotected by the vaccine than those who slept more than seven hours per night. Only the amount of sleep, not the quality of sleep, affected the amount of antibodies produced in response to the vaccine. More and more Americans are grappling with chronic sleep deprivation, these findings should be a wake-up call to the public health community about the clear connection between sleep and health, study author said. Based on the findings and laboratory evidence, physicians and other health professionals who are administering vaccines may want to consider asking their patients about their sleep patterns first, since a lack of sleep may affect the efficacy of the vaccine investigator said. Adults should get seven to nine hours of sleep per night, according to the National Sleep Foundation. While the study found an association between sleep and vaccine effectiveness, it did not prove a cause-and-effect relationship.

SOURCE: HealthDay News, August 2012

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                                                                          Signs of ADHD Evident by Preschool, Expert Says

One out of 11 school-aged children is diagnosed with attention-deficit/hyperactivity disorder (ADHD) and up to 40 percent of those kids may display symptoms in preschool, an expert says. Recognizing and treating the disorder early is important because ADHD has a profound effect on learning and academic development. Children whose symptoms begin in early childhood are at the highest risk for academic failure and grade repetition researcher noted. Investigator shows that children with ADHD have abnormal brain development, meaning that ADHD has a biological basis that often makes it a lifelong condition. Parents should pay close attention to the behavior of their young children. Children aged 3 to 4, the following behaviors are often associated with a diagnosis of ADHD by the time children reach school age: Avoids or dislikes activities that require more than one to two minutes of concentration; Loses interest in activities after a few minutes; Talks a lot more and makes more noise than other children the same age; Climbs on things despite being told not to; Unable to hop on one foot by the age of 4; Almost always restless and insists on getting up after being seated for only a few minutes; Acts fearless, which results in dangerous situations; Warms up to strangers too quickly; Behaves aggressively with friends; Has been injured after moving too fast or running after being told to slow down. Parents should consult with their pediatrician or another developmental expert if these symptoms are present. There are safe and effective treatments that can help manage symptoms, increase coping skills and change negative behaviors to improve academic and social success. Using neuroimaging, researcher recently found that children with ADHD have a smaller caudate nucleus (a small structure in the brain associated with thinking and motor control) than other children their age. The causes of ADHD aren't really known, although studies suggest that genes play a role. Scientists are also looking into whether brain injuries, diet and social environment contribute to the disorder. This research may help earlier interventions for children with ADHD.

SOURCE: HealthDay News, August 2012

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 Prostate Cancer !

Calcium, Vitamin D Supplements May Pose Risks for Prostate Cancer

Standard treatment for men with prostate cancer who are taking hormonal therapy, calcium and vitamin D supplements may do more harm than good, according to a new study. Men who undergo hormone-depletion therapy for prostate cancer are at risk for osteoporosis, but the supplements do not prevent this bone loss and may actually boost patients' odds for heart disease and aggressive prostate cancer, researcher suggests. Calcium and/or vitamin D supplementation to prevent loss of bone mineral density in these men seems so logical that no one had questioned whether it works. The problem is that there is evidence that calcium supplements increase the risk of cardiovascular disease and aggressive prostate cancer. In the study, the researchers reviewed guidelines for calcium and vitamin D supplements as well as the results of 12 clinical trials of these supplements involving almost 2,400 men with prostate cancer. All of the men were receiving hormone-deprivation therapy. The researchers also examined the men's bone mineral density before and after treatment. According to the study, the men undergoing hormone therapy for prostate cancer who took the recommended daily doses of calcium and vitamin D supplements lost bone density. The researchers also pointed out that increased dietary calcium is associated with a greater risk for aggressive prostate cancer and heart disease. The presumption of benefit from calcium and vitamin D supplements that have been routinely recommended to these men must be rigorously evaluated. The study's authors said more research is needed to confirm their findings and investigate the possible risks of calcium and vitamin D supplementation, particularly heart disease and prostate cancer. Not all men with prostate cancer need hormone therapy, only those with high-risk or advanced disease. And for those men, they need to have a discussion with their physician about the risks of these medications and how best to perhaps mitigate some of those risks.

SOURCE: HealthDay News, August 2012

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 Night-Time Cough !

Honey a Sweet Treatment for Kids' Night-Time Cough

Instead of reaching for a commercial medicine when child is coughing through the night because of a common cold, researchers suggest giving honey a try. A teaspoon or two of honey before bedtime can safely relieve the symptoms of an upper respiratory tract infection, they report. The cough due to a viral URTI is generally a self-limited disease. However, parents often want some active intervention. This often leads to the use of over-the-counter cough medications, which may potentially dangerous because of the possibility of accidental overdose and side effects. For this reason, honey may be a preferable treatment for the cough and sleep difficulty associated with childhood URTI. In light of the study, honey can be considered an effective and safe alternative, at least for those children over 1 year of age, researcher said. The authors pointed out that honey has long been appreciated for its antioxidant properties, derived from vitamin C and flavonoids among other sources. It is also known for its antimicrobial potential. Some researchers have suggested that the proximity of the nerve fibers that control coughing with the nerve fibers that control sweetness may empower sweet substances with a natural ability to suppress coughing. Still others believe the syrupy thickness of honey, alongside its ability to cause salivation (and thereby throat lubrication), are key characteristics that might explain its potential as an anti-coughing intervention. To test honey's therapeutic potential, researchers focused on 300 children between the ages of 1 and 5, all of whom had been diagnosed with URTI. The children had been ill for seven days or less and all suffered from night-time coughing and runny noses. None had signs of asthma or pneumonia. They were randomly given one of four possible treatments a half hour before bed: roughly two teaspoons of eucalyptus honey, citrus honey or libiatae honey or an extract that tasted and looked like honey but contained none. Based on parents' responses to a survey completed the day before treatment and the day after, the research team found that while all the children showed improvement in terms of sleep quality and coughing severity, those who received honey significantly better than those who consumed the non-honey extract. The authors thereby concluded that honey might be a ‘preferable treatment’ to relieve the kinds of symptoms that typify childhood upper respiratory infection.

SOURCE: HealthDay News, August 2012

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 Hypothermia !

Trauma Patients at Higher Risk of Dying of Hypothermia: Study

People who suffer a traumatic injury are at greater risk of dying from hypothermia, according to a new study. Hypothermia was defined as a body temperature below 95 degrees Fahrenheit. Risk of death from low body temperature is higher among those with more severe injuries, the researchers found. They cautioned that patients receiving emergency medical services should remain clothed when possible and temperatures of IV fluids and ambulances should be controlled. Researchers analyzed cases of adults with traumatic injuries who received pre-hospital care before being taken by ambulance to one of eight hospitals included in the study. The patients' body temperatures were monitored continuously using an infrared tympanic thermometer. Over the course of three years, 14 percent of patients had hypothermia by the time they arrived at the hospital. The severity of hypothermia was linked to the severity of injury the author said. Blood loss and spine or head injury impair body temperature regulation and in the study investigators found that head injury and intubation to aid breathing were independently associated with hypothermia. Although the temperature outside had little effect on patients' risk for hypothermia, the temperature of the IV fluids they were given and temperatures inside their ambulance were significant risk factors for the condition. The temperature of infused fluid for 75 percent of the patients was below 70 degrees and usually at ambient air temperature. Investigators suggest that, to reduce the incidence of hypothermia, the temperature of infusion fluids needs to be controlled and that as small a volume as possible is used. Temperature of infusion fluids can be easily and rapidly measured in pre-hospital settings. Researchers also recommend that ambulances be heated and that as much as possible the patient should remain clothed.

SOURCE: HealthDay News, August 2012

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 Kidney Stone !

Drinking Iced Tea Raises Kidney Stone Risk: Study

People who drink iced tea may be putting themselves at greater risk for developing painful kidney stones, a new study indicates. Researchers explained that the popular summertime drink contains high levels of oxalate, a chemical that leads to the formation of small crystals made of minerals and salt found in urine. Although these crystals are usually harmless, but can grow large enough to become lodged in the small tubes that drain urine from the kidney to the bladder. People who have a tendency to form the most common type of kidney stones, iced tea is one of the worst things to drink. Being dehydrated is the most common cause of kidney stones, the study authors pointed out. Drinking iced tea, however, can increase people's risk for the condition. People are told that in the summertime they should drink more fluids. A lot of people choose to drink more iced tea, because it is low in calories and tastes better than water. However, in terms of kidney stones, they might be doing themselves a disservice. Men are four times more likely to develop kidney stones than women. That risk jumps significantly for men over the age of 40. The researchers noted, however, that postmenopausal women with low estrogen levels and those who have had their ovaries removed are also at greater risk. To reduce the risk of kidney stones, the investigators advised people to stay hydrated. Although drinking water is best, they noted real lemonade is another good option. Lemons are high in citrates, which inhibit the growth of kidney stones. The study authors also advised that people at risk for kidney stones should take the following steps: Avoid foods with high levels of oxalates, including spinach, chocolate, rhubarb and nuts; Reduce salt intake; Eat less meat; Get enough calcium, which reduces the amount of oxalate absorbed by the body. Although hot tea also contains oxalates, the researchers noted it's hard to drink enough to cause kidney stones. 

SOURCE: HealthDay News, August 2012

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 New Products of SQUARE Pharmaceuticals Ltd.

  Product Bromolac
  Generic Name Bromocriptine
  Strength 2.5 mg
  Dosage form Tablet
  Therapeutic Category Anti-hyperprolactinemia
  Product Ansulin Pen Cartridge
Generic Name

Insulin Human rDNA

Strength 100 IU/ml
Dosage form Subcutaneous Injection
Therapeutic Category Human Insulin
  Product Zimax IV Infusion
  Generic Name Azithromycin
  Strength 500 mg/vial
  Dosage form IV Infusion
  Therapeutic Category Macrolides

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