Healthcare online Keeping you up-to-date
VOL.  11     ISSUE:  8    August  2013 Medical Services Department

SQUARE Pharmaceuticals Ltd.





P G Dip. Business Management





Dear Doctor,

Welcome to this edition of 'e-SQUARE'.

Our current issue focused on some interesting features like -
Aspirin Linked Ca !", ""BPA Alert" !", "Antibiotics Risk !", "Sleep Apnea Alert !",  "Fruit & AAA !", "Pregnancy Alert !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals Ltd. as well.

We will appreciate your feedback !

Click on to reply mode.

Yours sincerely,


Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals Ltd.

 Aspirin Linked Ca !

Aspirin Tied To Smaller Lung And Colon Cancer Tumors

Colon and lung cancer patients who regularly took low-dose aspirin before their diagnosis tended to have less advanced tumors, in a new study. Scientists already knew that aspirin was tied to a decreased risk of death for people with colon cancer, said senior author. "We showed evidence that it is also beneficial for lung cancer, and has both early and late protective effects," he added. However, the finding doesn't mean everyone should be taking aspirin to ward off advanced cancer, researchers said. They analyzed data that included 80,000 patients with colorectal, lung, prostate or breast cancer. One in four people with colorectal, lung or prostate cancer had regularly taken low-dose aspirin before being diagnosed - typically one 75-milligram tablet per day - compared to about one in seven breast cancer patients. The researchers found 20 to 40 percent fewer colon, lung and breast cancer patients who had taken aspirin had tumors that had spread to other areas of the body than those who had not taken aspirin. For example, 19 percent of regular aspirin users with colon cancer had metastatic disease, compared to close to 25 percent of non-users. Tumors on average were smaller and less advanced among aspirin users with colon and lung cancer, but not those with breast or prostate cancer, according to. "The mechanism is not fully understood," senior author said. Some researchers believe the anti-inflammatory and blood thinning effects of aspirin contribute to the lowered risk of certain cancers, he said. Researchers also aren't sure why aspirin would end up being beneficial for people who develop colon and lung cancer and not for breast or prostate cancer patients, though breast and prostate cancers often have more hormonal factors involved, he said. "Because it has side effects, it would be difficult if not impossible to prescribe aspirin to all people," he said. Ideally, only those at high risk for developing cancer would take aspirin. "Whether such an approach would benefit society as a whole deserves further studies," he said. 

SOURCE: Reuters Health, August 2013

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 BPA Alert !

              BPA Exposure Increases Risk Of Childhood Obesity And Abnormal Waist Circumference

Children who have higher levels of Bisphenol A (BPA), a chemical previously used in many products for kids, like baby bottle and plastic toys, had a higher odds of obesity and adverse levels of body fat, according to a new study. The research team studied the levels of BPA found in children's urine and then measured body fat, waist circumference, and cardiovascular and diabetes risk factors. BPA was previously widely used in the manufacturing of polycarbonate and epoxy resins used in a variety of products for children, including baby bottles, protective coatings on metal food containers, plastic toys, and dental sealants. "Studies in adults had shown an association between high BPA levels and obesity, diabetes and cardiovascular disease, but little was known about its effects in children," says lead author of the study. The study found that higher odds of obesity, defined as a BMI above the 95th percentile on Centers for Disease Control and Prevention growth curves, was associated with higher levels of urinary BPA. Researchers also found that children with higher BPA levels also were more likely to have an abnormal waist circumference-to-height ratio. The study did not find significant associations of BPA with any other chronic disease factors, including abnormal levels of cholesterol, insulin or glucose levels. "Our study suggests a possible link between BPA exposure and childhood obesity. We therefore need more longitudinal studies to determine if there is a causal link between BPA and excess body fat." researchers added. "Based on these results, BPA may not have adverse effects on cardiovascular and diabetes risk, but it's certainly possible that the adverse effects of BPA could compound over time, with health effects that only later manifest in adulthood," researcher said. 

SOURCE: Medical News Today, August 2013

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 Antibiotics Risk !

Certain Antibiotics Tied To Blood Sugar Swings In Diabetics

Diabetes patients who take a certain class of antibiotics are more likely to have severe blood sugar fluctuations than those who take other types of the drugs, a new study finds. The increased risk was low but doctors should consider it when prescribing the class of antibiotics, known as fluoroquinolones, to people with diabetes, the researchers said. This class of antibiotics, which includes drugs such as Ciprofloxacin, Levofloxacin and Moxifloxacin, is commonly used to treat conditions such as urinary tract infections and community-acquired pneumonia. One expert said the study should serve as a wake-up call for doctors. The study included about 78,000 people with diabetes. The researchers looked at the patients' use of three classes of antibiotics: fluoroquinolones; second-generation cephalosporins (cefuroxime, cefaclor, or cefprozil); or macrolides (clarithromycin or azithromycin). The investigators also looked for any emergency-room visits or hospitalizations for severe blood sugar swings among the patients in the 30 days after they started taking the antibiotics. The results showed that patients who took fluoroquinolones were more likely to have severe blood sugar swings than those who took antibiotics in the other classes. The level of risk varied according to the specific fluoroquinolone, according to the study. The incidence of hyperglycemia per 1,000 people was 6.9 for people taking moxifloxacin, 3.9 for levofloxacin and 4.0 for ciprofloxacin. The incidence of hypoglycemia was 10 per 1,000 for moxifloxacin, 9.3 for levofloxacin and 7.9 for ciprofloxacin. The incidence of hyperglycemia per 1,000 people was 1.6 for those taking the macrolide class of antibiotics and 2.1 for those on cephalosporins. The incidence of hypoglycemia per 1,000 people was 3.7 for macrolides and 3.2 for cephalosporins. They said doctors should consider other antibiotics if they have concerns that patients might experience severe blood sugar swings.

SOURCE: HealthDay News, August 2013

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 Sleep Apnea Alert !

Sleep Apnea May Be Linked To Glaucoma, Study Says

People with sleep apnea are at increased risk for glaucoma and should be screened for the eye disease, a new study suggests. Researchers examined the medical records of more than 1,000 people 40 and older who were diagnosed with sleep apnea between 2001 and 2004, and compared them to a "control" group of more than 6,000 people without sleep apnea. Those with sleep apnea were 1.67 times more likely to develop the most common type of glaucoma (open-angle glaucoma) within five years of their sleep apnea diagnosis than those in the control group, according to the study, published in the August issue of the journal Ophthalmology. Glaucoma is the second-leading cause of blindness worldwide. While previous research has found that glaucoma is more common among people with sleep apnea, this study concluded that sleep apnea is an independent risk factor for open-angle glaucoma. Sleep apnea -- characterized by disrupted breathing during sleep -- affects more than 100 million people worldwide, and nearly 60 million people have glaucoma. If untreated, glaucoma reduces peripheral vision and eventually may cause blindness by damaging the optic nerve. Only half of people with glaucoma are aware of it, because the disease is painless, and vision loss is typically gradual. All adults should get a baseline eye exam by age 40, when signs of disease and vision changes may start to occur, the American Academy of Ophthalmology advises. The study found an association between obstructive sleep apnea and open-angle glaucoma. It did not prove cause and effect.

SOURCE: HealthDay News, August 2013

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 Fruit & AAA !

Eating Fruit May Cut Risk Of Abdominal Aortic Aneurysm

Eating our daily quota of fruits and vegetables should be a no-brainer by now, as we have long heard of the health benefits accompanying a balanced diet. And now researchers have discovered that eating more fruit could lower risks for an often-lethal form of abdominal aortic aneurysm (AAA). After dividing over 80,000 people between the ages of 46 and 84 years into four groups based on the amount of fruit and vegetable they ate each day, the researchers then embarked on a 13-year follow-up study. During that time, they found that 1,086 people had abdominal aortic aneurysms, 222 of which ruptured. This type of aortic aneurysm involves a swelling of the lower part of the aorta, the body's main artery. Though rare, the researchers note, it is lethal in many cases. Men in the study accounted for over 80% of aneurysms, ruptured aneurysms included. Compared with the group who ate the least amount of fruit (less than one daily serving), those who ate the most fruit (over two servings) had a 25% lower risk of developing an aneurysm and a 43% lower risk of one that ruptured. Fruit juice did not count towards servings in the study. Additionally, compared with the group who did not eat any fruit at all, the high fruit-eaters had a 31% lower risk of an aneurysm and a 39% lower risk of a ruptured one. The types of fruits the subjects ate were mainly apples and pears, followed by bananas, oranges and other fruits of the citrus variety. The researchers say that abdominal aortic aneurysm is often asymptomatic and occurs in up to 4.5% of men over 65 years of age. In women of the same age group, up to 1.3% are affected. Though ultrasounds have been used for screening the condition, they say these abdominal aneurysms are highly likely to be lethal, citing a mortality risk of 70% before surgery and 35% after. The authors suggest that the high levels of antioxidants in fruit may be providing the protective effect, through inhibition of oxidative stress, which can encourage inflammation. Vegetables - also high in antioxidants - did not seem to affect the risk level for abdominal aortic aneurysm, possibly because some vegetables lack fruit antioxidants, say the researchers.  "Vegetables remain important for health. Other studies have found that eating more fruits and vegetables may decrease the risk of cardiovascular diseases, type 2 diabetes, high blood pressure, and several cancers" he added.  

SOURCE: Medical News Today, August 2013

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 Pregnancy Alert !

Pregnant And Obese: Early Deaths Noted Among Offspring

Here's another reason for young women to get their bad eating habits under control: Kids born to obese mothers are likely to die earlier than those born to normal-weight mothers, a new study suggests. In the United States and Europe, about two-thirds of women of reproductive age are overweight and more than one-third are obese, according to the study. Previous research has suggested that obesity during pregnancy may boost the risk of high blood pressure and high blood sugar, which are linked to cardiovascular disease, in their offspring. The findings of the new study are even more ominous. "We need to think about targeting children of obese mothers for lifestyle interventions to maintain a healthy weight," said study author. But the findings aren't conclusive, and it could be that the mothers' weight has nothing to do with the life spans of their children. It's possible, for example, that families with poor diets produce heavier moms and sicker kids. Also, even if the link is confirmed, it's not clear if these offspring can alter their extra risk of dying earlier, the researchers added. Earlier this year, a committee of the American College of Obstetricians and Gynecologists said all overweight or obese women should be offered nutrition counseling and be encouraged to follow an exercise program. For the study, the researchers tracked almost 38,000 people born in Scotland from 1950 onward who were aged 34 to 61 in 2011. They looked for data on the mothers body-mass index (BMI) -- a measurement of body fat based on height and weight -- and any deaths or heart disease among their children through that year. Overall, more than 6,500 deaths from any cause were reported, and the leading causes of death were cardiovascular disease and cancer. Those whose mothers were obese at birth -- meaning they had a BMI of 30 or higher -- were 35 percent more likely to have died by 2011 than those whose mothers were a normal weight. These young and middle-aged adults were also about 29 percent more likely to have been admitted to a hospital because of a heart problem; overall, 8 percent were admitted for that reason. The researchers came up with these numbers after adjusting their statistics to account for factors such as income level, gender, or maternal age at birth. Children of mothers who were overweight -- a BMI of 25 to 29 -- were 11 percent more likely to die than those of mothers of normal weight. The mechanisms behind this association aren't clear, and the researchers were lacking one crucial piece of information: whether the kids of obese pregnant moms became obese themselves. However, researcher said it's possible that genes play a role. Or, it's possible that the families of obese pregnant moms had poor eating habits that affected their children's health later on.

SOURCE: HealthDay News, August 2013

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 New Products of SQUARE Pharmaceuticals Ltd.

  Product Thyrin 25
  Generic Name Levothyroxine Sodium
  Strength 25 mg
  Dosage form Tablet
  Therapeutic Category Antihypothyroidism
  Product Rupatrol
Generic Name


Strength 10 mg
Dosage form Tablet
Therapeutic Category Antihistamine
  Product Iracet
  Generic Name Levetiracetam
  Strength 500 mg/5 ml
  Dosage form Oral Solution
  Therapeutic Category Antiepileptic

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