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Healthcare online Keeping you up-to-date
VOL.  13     ISSUE:  12  December   2015 Medical Services Department

SQUARE Pharmaceuticals Ltd.

Features

EDITORIAL TEAM

OMAR AKRAMUR RAB

MBBS, FCGP, FIAGP,

P G Dip. Business Management

MAHFUZUR RAHMAN

 MBBS, MBA

 

EDITORIAL

Dear Doctor,

Welcome to our healthcare bulletin "e- SQUARE".

This time, we have focused on some interesting features like -
"
Hormone Risk !", "Male Infertility Alert !", "Nasal Spray & DM !", "New Device !",  "Omega-3 !", "Toothlessness Alert !".

In our regular feature, we have some products information of SQUARE Pharmaceuticals Ltd. as well.

Please send your feedback !  We always value your comments !

On behalf of the management of SQUARE, we wish you all a very happy, healthy and prosperous life.

Click on to reply mode.

Yours sincerely,

 

Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals Ltd.

 Hormones Risk !

                                                                             Hormones Tied To Uterine Fibroid Risk In Study

Having high levels of the hormones testosterone and estrogen in mid-life may boost a woman's risk of benign tumors in the uterus called uterine fibroids, a new study suggests. "Our findings are particularly interesting because testosterone was previously unrecognized as a factor in the development of uterine fibroids," study co-author said. The study included nearly 1,400 women who had their testosterone and estrogen levels checked nearly every year for 13 years. Those with high levels of testosterone in their blood were 1.3 times more likely to develop uterine fibroids than those with low levels, and the risk was even greater in those with high levels of testosterone and estrogen, the investigators found. But while women with high levels of both hormones were more likely to have one case of uterine fibroids, they were less likely to develop them again than those with low levels of the hormones, according to the study published Dec. 15 in the Journal of Clinical Endocrinology & Metabolism. While testosterone is often called a male sex hormone, women also naturally produce small amounts of it, the study authors explained. "Our research suggests women undergoing the menopausal transition who have higher testosterone levels have an increased risk of developing fibroids, particularly if they also have higher estrogen levels," study co-author said. Three-quarters of women develop uterine fibroids by age 50, according to study author. Problems related to uterine fibroids include irregular bleeding, pelvic pain, infertility, recurrent pregnancy loss and other reproductive complications. While the study found an association between hormone levels and risk of uterine fibroids, it did not prove a cause-and-effect relationship.

SOURCE: HealthDay News, December 2015

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 Male Infertility Alert !

                                                     Infertile Men May Have Higher Risk Of Heart Disease, Diabetes

Infertile men may have a higher risk of developing other health problems such as diabetes, heart disease and substance abuse disorders, compared with fertile men, a new study suggests. "We found that infertile men developed several chronic diseases in the years following an infertility evaluation," lead researcher said. "What's interesting is that these are young, healthy men," he said. "Prior studies suggested a higher risk of [testicular] cancer or even death. But for the first time, we are seeing higher risk of these metabolic diseases." These findings suggest that infertility may provide a window into later health, he added. For the study, lead researcher and colleagues collected data on more than 100,000 men from an insurance claims database between 2001 and 2009. Their average age was 33. The researchers zeroed in on general health conditions of three groups of males: men diagnosed with infertility, men who didn't receive an infertility diagnosis and men who had had a vasectomy, who were presumed to be fertile. The researchers found that infertile men had a 48 percent higher rate of heart disease and about 30 percent higher odds of diabetes, even after compensating for obesity and smoking. They also had higher rates of alcohol and drug abuse, the researchers said. Moreover, those with the most severe form of infertility had the highest risk of kidney disease and alcohol abuse, he said. The study doesn't establish a direct cause-and-effect relationship between infertility and chronic diseases, however. But, the researchers speculated that hormonal and/or environmental factors may be involved. Lower levels of testosterone in infertile men may be linked to higher rates of death and heart disease, they suggested. Also, exposure to harmful environmental influences during fetal development might lead to both reproductive and general health problems later in life, lead researcher said. Perhaps some of the same exposures that are related to heart disease later in life also reduce sperm count, he said. "Thus, when a couple presents for infertility, there may be an opportunity to make a positive impact on a man's health through an evaluation of his fertility," he added.

SOURCE: HealthDay News, December 2015

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 Nasal Spray & DM !

                                       Nasal Spray May Give Diabetics Faster Treatment For Low Blood Sugar

A new nasal spray might make rescue care easier for diabetics who are woozy or even unconscious due to severe low blood sugar, a new clinical trial suggests. The nasal spray contains powdered glucagon, a hormone that causes a prompt increase in blood sugar levels. The trial results showed that the nasal spray is nearly as effective in treating hypoglycemia as the only option currently available, a glucagon powder that must be mixed with water, drawn into a syringe and then injected into muscle. People with diabetes mellitus (DM) trying to walk the tightrope of precise blood sugar control sometimes take too much insulin, which causes their blood sugar levels to drop drastically, the researchers said in background notes. In mild or moderate cases, diabetics can correct their blood sugar by drinking some orange juice or sucking on hard candy. But the most severe episodes might require treatment using glucagon. To test whether the new nasal spray is as effective as the injection, researchers recruited 75 adults with type 1 diabetes at eight clinics in the United States. All participants underwent induced hypoglycemia twice, and then received treatment once using the injection and once with the nasal spray. The nasal spray worked about 99 percent of the time, while the injection was 100 percent effective, according to the trial results. It took slightly longer for the nasal spray to suitably increase blood sugar levels -- about 16 minutes, on average -- compared with 13 minutes for the injection. However, the researchers noted that an earlier study showed that it takes just 16 to 26 seconds to administer the nasal spray, versus 1.9 to 2.4 minutes to give the injection, depending on the training of the caregiver. Both forms of glucagon produced nausea in a little more than a third of users. People using the nasal spray were more likely to report head and facial discomfort. The trial results were published online Dec. 17 in the journal Diabetes Care.

SOURCE: HealthDay News, December 2015

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 New Device !

                                                                                New Device Approved For Fecal Incontinence

The Fenix Continence Restoration System has been approved by the U.S. Food and Drug Administration to treat an inability to control bowel movements for people who can't tolerate or use other approved methods. The inability to control the bowels, medically called fecal incontinence, is most often caused by muscle damage from vaginal childbirth or from certain medical disorders such as diabetes, the agency said in a news release. The Fenix system was evaluated in 35 adults, 15 of them from the United States. U.S. trial participants will be examined for five additional years to evaluate the device's performance, the FDA said. The system should not be implanted in people with known or suspected allergies to titanium, stainless steel, nickel or iron. And people who have had the device implanted should not have a magnetic resonance imaging (MRI) scan, the agency warned. Side effects of the system have included pain, infection, device erosion, additional surgery to remove the device, and bleeding. 

SOURCE: HealthDay News, December 2015

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 Omega-3 !

                                                       Omega-3 Fatty Acids May Play Role In Bipolar Disorder: Study

A small study suggests there may be a link between levels of omega-3 fatty acids and bipolar disorder. Researchers compared 27 people with bipolar disorder and 31 people without the mental illness. Those with bipolar disorder had lower levels of certain omega-3 fatty acids that can cross the blood-brain barrier, the study authors found. Omega-3 fatty acids play an important role in communication between brain cells, and fatty acids are a major player in the immune and inflammatory systems, the researchers said. "Omega-3 and omega-6 fatty acids can shift the balance of inflammation, which we think is important in bipolar disorder," study leader said. Foods such as fish, vegetable oils, nuts, flax seeds and flaxseed oil, as well as leafy vegetables, are rich in omega-3 fatty acids. The study found no difference in reported consumption of these foods between the two groups of participants. The researchers said they don't know if that's because only certain foods were included in the survey or because people couldn't accurately recall what they had eaten. They are now looking at whether increasing the amount of fatty acids in bipolar patients' diets may benefit them. "We are actively pursuing the next step in this line of inquiry, to get to the point where we know what changes in diets are going to help people with bipolar disorder so they can have another option beyond the medications that are currently available," study leader added. Previous research has found that omega-3 supplements provided no benefit for people with bipolar disorder, the researchers added. The study was published recently in the journal Bipolar Disorders.

SOURCE: HealthDay News, December 2015

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 Toothlessness Alert !

                                                                            Toothlessness A Clue To Deadly Heart Disease ?

Toothless heart disease patients are nearly twice as likely to die as those who have all their teeth, a new study suggests. Gum disease is the most common cause of tooth loss, and gum disease-related inflammation is believed to play a role in the narrowing of arteries, the researchers said. "While we can't yet advise patients to look after their teeth to lower their cardiovascular risk, the positive effects of brushing and flossing are well established. The potential for additional positive effects on cardiovascular health would be a bonus," study lead author said. The study included more than 15,000 heart disease patients in 39 countries. They were assessed for tooth loss and followed for an average of 3.7 years. Those with the fewest teeth were older, smokers, female, less active and more likely to have diabetes, high blood pressure, more body fat and a lower level of education, the study found. During the follow-up, more than 1,500 major events -- either cardiovascular death, heart attack or stroke -- occurred, as well as 705 cardiovascular deaths, 1,120 deaths from any cause, and 301 strokes. After adjusting for certain factors, the researchers concluded that every increased level of tooth loss was associated with a 6 percent increased risk of major cardiovascular events, and a roughly 15 percent higher risk of cardiovascular death, death from any cause and stroke. Compared to patients with all their teeth, those with no teeth had a 27 percent higher risk of major cardiovascular events. The researchers also found toothlessness was associated with an 85 percent higher risk of cardiovascular death, 81 percent higher risk of death from any cause, and a 67 percent higher risk of stroke. The study only found a link, not a cause-and-effect relationship, between dental health and heart health. It was published Dec. 16 in the European Journal of Preventive Cardiology. "The risk increase was gradual, with the highest risk in those with no remaining teeth," study author said. "For example the risks of cardiovascular death and all-cause death were almost double to those with all teeth remaining. Heart disease and gum disease share many risk factors such as smoking and diabetes but we adjusted for these in our analysis and found a seemingly independent relationship between the two conditions," researcher explained. Among study participants, around 16 percent had no teeth, and roughly 40 percent were missing half of their teeth, study author noted. "This was an observational study so we cannot conclude that gum disease directly causes adverse events in heart patients. But tooth loss could be an easy and inexpensive way to identify patients at higher risk who need more intense prevention efforts," study author said.

SOURCE: HealthDay News, December 2015

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 Products of SQUARE Pharmaceuticals Ltd.

  Product Paloset  
  Generic Name Palonosetron
  Strength 0.5 mg
  Dosage form Tablet
  Therapeutic Category Antiemetic
  Product Luraprex
Generic Name

Lurasidone HCl 

Strength 40 mg
Dosage form Tablet
Therapeutic Category Antipsychotic
  Product Calborate
  Generic Name Calcium Orotate 
  Strength 740 mg
  Dosage form Tablet
  Therapeutic Category Calcium Supplement

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