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VOL.  11     ISSUE:  12  December   2013 Medical Services Department

SQUARE Pharmaceuticals Ltd.


Dear Doctor:

Welcome to this edition of 'e-SQUARE' .

Our current issue focused on some interesting features like-

"Harmless Lung Cancer !", "Heartbeat & Depression !", "Kids' Cough !"Pregnancy Snoring Alert !", "Exercise & Stones !", "Superbug !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals Ltd. as well.

We will appreciate your feedback !

Click on to reply mode.

Yours sincerely,


Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE PHARMACEUTICALS LTD.

 Harmless Lung Cancer !

 Many Lung Cancer Tumors May Prove Harmless, Study Finds

Smokers who have a CT scan to check for lung cancer stand a nearly one-in-five chance that doctors will find and potentially treat a tumor that would not have caused illness or death, researchers report. Despite the finding, major medical groups indicated they are likely to stick by current recommendations that a select segment of long-time smokers undergo regular CT scans. Some researchers argue that many people receive painful and life-altering treatments for cancers that never would have harmed or killed them. The new study used data gathered during the National Lung Screening Trial, a major seven-year study to determine whether lung CT scans could help prevent cancer deaths. The trial found that 20 percent of lung cancer deaths could be prevented if doctors perform CT screening on people aged 55 to 79 who are current smokers or quit less than 15 years ago. To qualify for screening, the participants must have a smoking history of 30 pack-years or greater. In other words, they had to have smoked an average of one pack of cigarettes a day for 30 years. Based on the study findings, the American Lung Association, the American Cancer Society, the American College of Radiology and other medical associations recommended regular screenings for that specific segment of the smoking population. The latest projections from that same data, however, found that more than 18 percent of the cancers detected by the scans would be unlikely to do harm to the patient, said study co-author. He characterized his findings as "one piece of information they were waiting for just to understand the risks and limitations of the trial and of recommending mass screening." "When we tell patients we're going to do a test, you need to understand the risks and benefits," he said. "This is just part of the equation." A member of research team said, some of the over-diagnosis can be attributed to slow-growing tumors. In other cases, however, smokers will not die of cancer because they will succumb first to emphysema, heart disease or the myriad of other major health problems caused by smoking. "It could be that heavy smokers die of lots of other things before the cancer can kill them," he added. Study co-author said the results highlight the need for future research to uncover genetic markers that will allow doctors to better sort aggressive cancers from cancers that might not need to be treated.

SOURCE: HealthDay News, December 2013

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 Heartbeat & Depression !

Irregular Heartbeat Tied To Depression

People with an irregular heartbeat may also be at increased risk of being depressed, a new study suggests. The added risk was small, researchers found, but it's in keeping with other studies linking heart disorders with depression. Atrial fibrillation (AF) is a type of rhythm disorder affecting the heart's upper chambers. It can be caused by a number of issues - including heart attacks, infections and heart valve problems. Obesity is a risk factor for AF, as are high blood pressure, high cholesterol and diabetes. Doctors have long known that patients' mental state can affect how well they take care of themselves, follow treatment instructions and how they perceive the burden of their illnesses. Lead researcher and her fellow wanted to see if depression might affect the course of atrial fibrillation and patients' feelings about their disease. Her team used data on 10,000 German adults for the new study. Most did not have AF, but 309 did. The researchers compared the average depression scores for people with AF to the scores of people without the condition. Depression was measured on a scale of zero to 27, with higher scores indicating more severe depression. On average, people with AF scored a four, compared to an average score of three among those without the irregular heartbeat. In either group's case, the score wouldn't be enough to warrant treatment for depression. Lead researcher and her colleagues did find that the difference in depression severity they saw was mostly driven by the physical symptoms of depression, such as aches and pains, being more common or intense in people with irregular heartbeats. Screening for and treating depression symptoms might help heart patients to feel better physically and potentially even improve their heart conditions, the researchers write.

SOURCE: Reuters Health, December  2013

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 Kids’ Cough !

Kids' Coughs, Colds May Last Weeks But Don't Need Drugs

Children's coughs and colds can last up to two or three weeks and earaches may take a week to get better, according to a new review of past studies. Researchers said they hope the findings help reassure both doctors and parents that respiratory symptoms can last "longer than previously appreciated" but typically don't require treatment. For their review, lead author and his colleagues analyzed the results of 48 studies of children with a respiratory tract infection. Kids in those studies were treated with over-the-counter medicines, drug-free placebo pills or nothing. Researchers followed them to see when their symptoms went away. Among children with earaches, 90 percent were better within seven to eight days of visiting a primary care doctor or the emergency room. Most kids with the common cold were better after 15 days, while it took 25 days for almost all children with a cough to be fully recovered. Sore throats typically lasted anywhere from two to seven days, depending on the study. The duration of earaches and common colds in particular was "considerably longer" than parents in the U.S. and UK are generally told, the researchers wrote. What's more, using antibiotics could have long-term implications by increasing the chance that bugs become resistant to the drugs, making future infections harder to treat.

SOURCE: Reuters Health, December 2013

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 Pregnancy Snoring Alert !

Snoring In Pregnancy Tied To More C-section & Small Baby

Pregnant women who snore three or more nights a week are more likely to have a cesarean section and smaller babies, a new study finds. The findings suggest that treating snoring in pregnant women may help reduce health problems among newborns and the associated medical costs, according to the researchers. They looked at 1,673 pregnant women, 35 percent of whom reported regular snoring. Compared to non-snorers, those who snored before and during pregnancy (chronic snorers) were two-thirds more likely to have a small baby and more than twice as likely to have an elective C-section. "There has been great interest in the implications of snoring during pregnancy and how it affects maternal health, but there is little data on how it may impact the health of the baby," lead author said. "We've found that chronic snoring is associated with both smaller babies and C-sections, even after we accounted for other risk factors. This suggests that we have a window of opportunity to screen pregnant women for breathing problems during sleep that may put them at risk of poor delivery outcomes," she explained. A previous study found that women who begin snoring during pregnancy are at high risk for high blood pressure and preeclampsia -- a condition in which a pregnant woman experiences sharp rises in blood pressure along with protein in her urine and other symptoms. Snoring is a key sign of obstructive sleep apnea, which can be treated using continuous positive airway pressure (CPAP). "Millions of health care dollars are spent on operative deliveries, taking care of babies who are admitted to the NICU and treating secondary health problems that smaller babies are at risk for when grown," she said. "If we can identify risks during pregnancy that can be treated, such as obstructive sleep apnea, we can reduce the incidence of small babies, C-sections and possibly NICU admission that not only improve long- term health benefits for newborns but also help keep costs down," she said. While the study found associations between snoring in pregnancy and an increased likelihood of C-section delivery and smaller babies, it did not establish a cause-and-effect relationship.

SOURCE: HealthDay News, November 2013

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 Exercise & Stones !

Light Exercise Might Reduce Risk Of Kidney Stones

Just a little exercise each week -- jogging for an hour or walking for about three hours -- can reduce the risk of developing kidney stones by up to 31 percent, according to a new study. Researchers looking at data on more than 84,000 postmenopausal women found that engaging in any type of light physical activity can help prevent the formation of these pebbles in the kidneys. Even light gardening might curb their development, according to the study. "Even small amounts of exercise may decrease the risk of kidney stones," said study author. "It does not need to be marathons, as the intensity of the exercise does not seem to matter." Kidney stones, which have become increasingly common, are more prevalent among women. During the past 15 years, research has shown that kidney stones might actually be a systemic problem, involving more than just the kidneys. Recent research has linked the stones to obesity, diabetes, metabolic syndrome and heart disease. In conducting the study, the researchers analyzed information compiled since the 1990s on the women's eating habits and level of physical activity. After taking into account the women's body-mass, the researchers found that obesity was a risk factor for the development of kidney stones. Eating more than 2,200 calories a day could increase the risk for kidney stones by up to 42 percent, they found. "Being aware of calorie intake, watching their weight and making efforts to exercise are important factors for improving the health of our patients overall, and as it relates to kidney stones," study author said. The study did not, however, prove a cause-and-effect link between exercise and decreased risk for kidney stones. It showed only an association between the two in a small portion of the population. 

SOURCE: HealthDay News, December 2013

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 Superbug !

E. Coli 'Superbug' May Pose Major Health Threat: Study

A single strain of antibiotic-resistant E. coli bacteria has become the main cause of bacterial infections in women and the elderly worldwide over the past decade and poses a serious health threat, researchers report. Along with becoming more resistant to antibiotics, the "H30-Rx" strain developed the unprecedented ability to spread from the urinary tract to the bloodstream and cause an extremely dangerous infection called sepsis. This means that the H30-Rx strain poses a threat to the more than 10 million Americans who develop a urinary tract infection each year, according to the study authors. Lead researcher said this strain appears to be much more able than other E. coli strains to move from the bladder to the kidneys and then into the bloodstream. H30-Rx may be responsible for 1.5 million urinary tract infections and tens of thousands of deaths each year in the United States, according to the study. Genetic analyses revealed how H30-Rx came into being. More than two decades ago, a strain called H30 developed mutations in two genes. This resulted in a clone called H30-R, which was resistant to the antibiotic Cipro. Soon after, H30-R gave rise to H30-Rx, which is resistant to several antibiotics. By focusing on H30-Rx, it might be possible to develop a vaccine that could prevent many infections, according to the study authors. "This strain of E. coli spreads from person to person, and seems to be particularly virulent," study co-author said. "This study might help us develop better tools to identify, stop or prevent its spread by finding better ways to block the transmission of the superbug, or by finding a diagnostic test that would help doctors identify such an infection early on -- before it might have the chance to turn lethal," he explained. "We now know that we are dealing with a single enemy, and that by focusing on this strain we can have a substantial impact on this worldwide epidemic," study co-author said.

SOURCE: HealthDay News, December 2013

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New Products of SQUARE Pharmaceuticals Ltd.

  Product Comprid® XR 60
  Generic Name Gliclazide
  Strength 60 mg
  Dosage form XR Tablet
  Therapeutic Category Oral Antidiabetic
  Product Ticamet® 50 HFA Inhaler
Generic Name



(25mcg+50 mcg)/puff

Dosage form MDI
Therapeutic Category Antiasthma
  Product Flacol® Chewable Tablet
  Generic Name Simethicone

40 mg

  Dosage form Tablet
  Therapeutic Category Antiflatulent

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