Healthcare online Keeping you up-to-date
VOL.  11     ISSUE:  1  January  2013 Medical Services Department

SQUARE Pharmaceuticals Ltd.





P G Dip. Business Management

A. S. M. Shawkat Ali

MBBS, M. Phil





Dear Doctor,

Welcome to this edition of e- SQUARE.

In this issue, we focused on some interesting features like -
ADHD Alert !", "Brain Tumor !", "Gut Bug !", "Blood Clots In IVF !",  "Jaw Pain !", "Overactive Bladder !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals Ltd. as well.

Please send your feedback !  We always value your comments !

On behalf of the management of SQUARE, we wish you all a very happy, healthy and prosperous life.

Click on to reply mode.

Yours sincerely,


Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals Ltd.

 ADHD Alert !

More U.S. Children Diagnosed With ADHD

More and more U.S. children are being diagnosed with attention-deficit/hyperactivity disorder, a new study suggests. Exactly why these rates are climbing isn't clear. But increased awareness of attention-deficit/hyperactivity disorder (ADHD), is likely a contributing factor. According to the new findings, the rate of children who were diagnosed with ADHD jumped by about 24 percent between 2001 and 2010. This increase was most pronounced with white children and there was a 90 percent increase in ADHD diagnosis among black girls during the same time frame. The U.S. Centers for Disease Control and Prevention (CDC) estimates that between 4 percent and 12 percent of school-aged children have ADHD. Symptoms include difficulty focusing, impulsive behaviors and hyperactivity. For the study, researchers collected data from nearly 850,000 children aged 5 to 11 years between 2001 and 2010. Of these children, slightly less than 5 percent had an ADHD diagnosis. White and black children were more likely to be diagnosed with ADHD than Hispanics and Asian/Pacific Islander children. Specifically 5.6 percent of white children in the study had an ADHD diagnosis in 2010, compared with 4.1 percent of blacks, 2.5 percent of Hispanics and 1.2 percent of Asian/Pacific Islanders. Boys were three times more likely to be diagnosed with ADHD than girls, the study found. Study author said that this increasing trend of ADHD diagnoses could be due to more awareness among doctors and increased use of screening tools, but it also could mean that ADHD is becoming more common. The trend has increased, but the reason behind it is just speculation and most likely a result of heightened awareness. Of note, the gender gap is getting smaller among black children, but not other groups. The increase in ADHD over time is likely due to increased recognition of the disorder. As awareness grows, certain racial and ethnic groups who previously fell under the radar are beginning to be diagnosed. Still, despite the increase in rates of diagnosis, ADHD remains under diagnosed in some populations, especially poor and minority groups. It may be over diagnosed in others, however. The new study backs up this point that, privileged children who are in very competitive schools and there is tremendous pressure to perform better and this may result in diagnosis of ADHD. Families with higher incomes were more likely to have ADHD diagnoses than poorer families, the researchers found. Treatments for ADHD include medication and behavioral modifications. Earlier diagnosis and treatment leads to better outcomes for these children.

SOURCE: HealthDay News, January 2013

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 Brain Tumor !

Scientists Link More Genes to Common Brain Tumor

Abnormalities in just five genes account for the majority of meningioma brain tumors, according to a new study. Meningiomas are the most common type of brain tumor. They are usually benign but are cancerous in about 10 percent of cases. Surgery is the only treatment for meningiomas, but this finding could help lead to new therapies tailored to individual patients, according to the study. Previous research found that about half of meningiomas were linked to a mutation or deletion of a gene called neurofibromin 2. The genetic origin of the other types of meningiomas was unknown. In this study, researchers analyzed samples from 300 meningiomas and found that abnormalities in four other genes are also linked to the brain tumors. Each of these genes tends to be associated with tumors in different areas of the brain. Location can indicate how likely meningiomas are to become cancerous. Combining knowledge of these mutations with the location of tumor growth has direct clinical relevance and opens the door for personalized therapies, said the investigator. Personalized therapies could include treating some patients with chemotherapy only or sparing vulnerable patients from radiation therapy, according to the study.

SOURCE: HealthDay News, January 2013

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 Gut Bug !

Vaccinating Kids Against Common Gut Bug Helps Shield Adults Too

A new study finds that vaccinating children against rotavirus may also help protect unvaccinated adults against the highly contagious virus that causes severe diarrhea and vomiting. Before vaccination was introduced, rotavirus caused 2.4 million hospitalizations and more than 450,000 deaths in infants and children globally each year. After vaccination was introduced in the United States, declines in rotavirus infection were seen in both vaccinated and unvaccinated children. This study examined whether the vaccine's benefits also extend to unvaccinated adults. The researchers compared the prevalence of rotavirus in stool samples collected from 3,500 adults in 2006 and 2007 before widespread implementation of rotavirus vaccination in children and in samples collected from 2008 to 2010. There were nearly 50 percent fewer unvaccinated adults with rotavirus in the second round of samples, according to the study. Significant declines were seen in both adults admitted to the hospital and those treated as outpatients. Previous research estimated that adult inpatient hospital charges related to rotavirus are $152 million a year in the United States. These new findings suggest that vaccinating children against rotavirus may be much more cost effective than previously believed, said study author. Vaccinating children may protect adults from rotavirus by decreasing the amount of rotavirus circulating in the community, investigator said. The findings highlight the need to support and encourage vaccination. By improving the health of children, we indirectly improve the health of adults, researcher added.

SOURCE: HealthDay News, January 2013

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  Blood Clots In IVF !

Blood Clots During Pregnancy More Likely After IVF

Women who became pregnant through in vitro fertilization (IVF) may have an increased risk of developing blood clots and potentially fatal artery blockage, the researchers said. Although the risk remains small, the odds are especially high during the first trimester compared to women who become pregnant naturally, investigators suggest. Blood clots, called venous thromboembolism-can develop in the leg veins and break free, traveling to the lungs and blocking a main artery. This condition, called pulmonary embolism, can cause difficulty breathing and even death. There is an increased incidence of pulmonary embolism and venous thrombosis among women pregnant after IVF, said lead researcher. Embolism is the leading cause of maternal mortality during pregnancy. The diagnosis can be elusive, so physicians should be aware of this risk to facilitate the diagnosis. The risk of clotting during pregnancy isn't confined to women who undergo IVF, other experts said. Any pregnancy carries a risk of clotting. This is because hormones, particularly estrogen, increase during pregnancy. This changes the clotting cascade. There are many factors in blood clotting that can be affected by hormones-especially estrogen. In addition, the enlarging uterus puts pressure on pelvic blood vessels, which can lead to clotting. Although it's unclear why women who undergo IVF have a greater risk of clotting. Researcher speculates that it could be due to fertility treatments that increase estrogen even beyond levels normally associated with pregnancy. The genetics of women who need IVF to conceive may also be a factor. For the study, researchers compared data on more than 23,000 women who became pregnant after IVF with nearly 117,000 women who conceived without assisted technology. Researchers found that for women who had undergone IVF, the risk for a blood clot was 4.2 in 1,000 women. For the women with normal pregnancies, the risk was 2.5 in 1,000. Moreover, the risk was highest during the first trimester. Pulmonary embolism occurred in 19 women who had IVF (8.1 out of 10,000) compared with 70 women who conceived normally (6.0 out of 10,000), the study found. Investigators caution that the absolute risk of a pulmonary embolism among women who had IVF was still slight two to three additional cases in 10,000 women. Also, most blood clots do not go to the lungs and can easily be treated and resolved. Women at risk for clots can be treated with blood thinners that prevent clots, researcher said.

SOURCE: HealthDay News, January 2013

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 Jaw Pain !

Jaw Pain Disorder Tied to Anxiety, Depression

There's a link between depression and anxiety symptoms and temporomandibular joint (TMJ) disorder pain, a condition that affects the jaw, according to a new study. TMJ disorders affect the muscles and joints that connect lower jaw to the skull. For the study researchers included more than 4,000 patients who underwent medical and oral health examinations and TMJ pain assessments  and completed a psychiatric risk factor questionnaire. The researchers found that depressive symptoms were more strongly related to TMJ pain than to muscle pain, while anxiety symptoms were linked with muscle pain. TMJ pain may be a physical symptom of depression or anxiety, according to the researchers. They explained that these mental health conditions could lead to increased activity in the jaw muscles that could cause inflammation and pain. It's also possible that chemical imbalances in the brains of people with depression and anxiety could lead to abnormal processing of pain sensation, according to the investigator. Previous research has suggested a link between depression and TMJ pain, the authors of the new study pointed out. Based on their findings, researchers concluded that there is a moderate to strong link between depression and anxiety symptoms and TMJ pain. However, the association between TMJ pain and anxiety and depression does not prove that there is a cause-and-effect relationship.

SOURCE: HealthDay News, January 2013

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 Overactive Bladder !

1st OTC Drug Approved for Women With Overactive Bladder

The drug Oxytrol has been approved by the U.S. Food and Drug Administration as the first over-the-counter treatment for women 18 and older with overactive bladder. Overactive bladder is characterized by symptoms including leakage, frequent urination and feeling the sudden and urgent need to urinate. The condition affects some 33 million Americans, mostly older women.Oxytrol contains oxybutynin, among a class of drugs called anticholinergics that are designed to relax the bladder muscle. Oxytrol is a patch applied to the skin every four days. The drug will remain available for adult men by prescription only, the agency said.Side effects reported during clinical testing included skin irritation at the patch site, dry mouth and constipation.

SOURCE: HealthDay News, January 2013

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New Products of SQUARE Pharmaceuticals Ltd.

  Product Intimate 
  Generic Name Tadalafil
  Strength 5,10,20 mg
  Dosage form Tablet
  Therapeutic Category Erectyle Dysfunction
  Product Epitra
Generic Name


Strength 1 mg
Dosage form Tablet
Therapeutic Category Antiepileptic
  Product Prosalic
  Generic Name Betamethasone+Salicylic Acid
  Strength 0.05%+2%
  Dosage form Lotion
  Therapeutic Category Topical Corticosteroid Combination

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