Healthcare online Keeping you up-to-date
VOL.  14     ISSUE:  5   May 2016 Medical Services Department

SQUARE Pharmaceuticals Ltd.





P G Dip. Business Management





Hope that you are enjoying this online healthcare bulletin.

Our current issue focused on some interesting features like -

"Ca-Cervix Risk !", "Folic Acid & Mom !", "'Sunscreen' Gene !", "Fatty Foods Alert !",  "Weight & Ca-Colon !", "Newer Drugs !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals Ltd. as well.

We will appreciate your feedback !

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Yours sincerely,


Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals Ltd.

 Ca-Cervix Risk !

Inactive Women May Face Higher Risk for Cervical Cancer

Women who are sedentary appear more likely to develop cervical cancer (Ca-Cervix), but just 30 minutes of exercise each week might significantly reduce that risk, new research suggests. "We think that this study sends a powerful public health message: that a complete lack of exercise is associated with the greater likelihood of developing a serious disease," senior study author said. "Our findings show that any amount of exercise can reduce cervical cancer risk," study author added. The researchers believe that "this is the first U.S.-based study looking at the associations between physical inactivity and cervical cancer." "Our findings suggest that abstinence from regular physical activity is associated with increased odds of cervical cancer," he added, although a cause-and-effect link was not proven. The study involved 128 women diagnosed with cervical cancer, as well as 512 women who were suspected of having cervical cancer but ultimately were found not to have the disease. Of those diagnosed with cervical cancer, 31 percent of the women reported being inactive. In this study, physical inactivity was defined as exercising less than four times a month. Even after the researchers considered other risk factors -- such as smoking, alcohol intake, family history of cervical cancer and body mass index -- these women were 2.5 times more likely to develop cervical cancer than women who exercised, the findings showed. Meanwhile, 26 percent of the women who had been suspected of having cervical cancer reported being inactive, the investigators found. "In addition to smoking cessation and undergoing regular screening, we have identified another important modifiable risk factor for this disease," study author added. The findings were published in the May issue of the Journal of Lower Genital Tract Disease.

SOURCE: HealthDay News, May 2016

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 Folic Acid & Mom !

 Folic Acid for Moms-to-Be Not as Effective as Thought?

Fortifying cereals, grains and flour with folic acid has not protected against the risk of certain birth defects as much as experts thought it would, a large, new study suggests. In the late 1990s, health experts found that low folic acid blood levels were linked to both birth defects. So, the U.S. Food and Drug Administration mandated that cereal and grain products be fortified with the B vitamin. To measure just how effective that effort has been, investigators analyzed 1.3 million births across eight central California counties over two decades. Between 1989 and 2010, there was an average of about 88 cases of neural tube defects for every 100,000 births. But digging deeper, investigators found that that risk had already started to decline before the 1997 fortification mandate. There was a risk drop of nearly 9 cases per 100,000 births every year between 1989 and 1996 alone, the researchers said. And that downward trend actually slowed after fortification, dipping by 1.7 cases for every 100,000 births annually between 1999 and 2010, the study authors said. Study co-author said a number of unexamined factors might have played a role in the trend, including a notable rise in maternal obesity. "And we now have to wonder if folic acid is the whole answer," he said. "What we do know, however, is that this is not a message to women that they should now do anything differently," he stressed. "I certainly do not want to convey that folic acid doesn't work. We're all very grateful that we found folic acid a while back. And it works." That thought was seconded by a public health analyst with the U.S. National Center on Birth Defects and Developmental Disabilities, part of the Centers for Disease Control and Prevention. "CDC researchers have found that since folic acid fortification began in the United States, about 1,300 babies are born each year without a neural tube defect who might otherwise have been affected," she said. "Folic acid has been shown to be effective in preventing neural tube defects in randomized control trials, community intervention programs and food fortification programs," she added. The bottom line? "The benefits of folic acid for the prevention of neural tube defects are well-documented," public health analyst of CDC said. "The CDC continues to recommend that, to reduce their risk for a neural tube defect-affected pregnancy, women capable of becoming pregnant should take 400 micrograms of synthetic folic acid daily, from fortified foods or supplements or a combination of the two, in addition to consuming food with folate from a varied diet." Study co-author and his colleagues reported their findings online May 18 in the journal Birth Defects Research Part A. 

SOURCE: HealthDay News, May 2016

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 'Sunscreen' Gene !

'Sunscreen' Gene May Guard Against Skin Cancer

Scientists say they've identified a so-called "sunscreen" gene that may help protect against skin cancer. They say the finding potentially could lead to new drugs to prevent the disease. The investigators pinpointed the ultraviolet-resistant gene after analyzing data from 340 people with melanoma, the deadliest type of skin cancer, and conducting laboratory experiments. "If we understand how this UV-resistant gene functions and the processes by which cells repair themselves after ultraviolet damage, then we could find targets for drugs to revert a misguided mechanism back to normal conditions," study senior author said. Cell damage from exposure to UV radiation causes more than 90 percent of melanoma skin cancers. Melanoma kills more than 10,000 people in the United States each year, according to the American Cancer Society. "People who have the mutated UV-resistant gene or low levels of the UV-resistant gene may be at higher risk of melanoma or other skin cancers, especially if they go sunbathing or tanning frequently," study author said. "Our study suggests that the UV-resistant gene may serve as a biomarker for skin cancer prevention," study author added. The investigators will conduct research with mice to learn more about how the UV-resistant gene functions. "The UV-resistant gene may serve as a good target for drug development," study author said. Perhaps one day a drug could stimulate the repair function of the UV-resistant gene to ensure swift and effective repair of UV-damaged skin cells, study author added. "That would be a good treatment for people who are at high risk of developing skin cancer," the researcher concluded. The findings were published May 19 in the journal Molecular Cell.

SOURCE: HealthDay News, May 2016

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 Fatty Foods  Alert !

                                         Fatty Foods During Teen Years May Influence Later Breast Cancer Risk

Teens who eat high amounts of saturated fats or low amounts of healthier mono- and polyunsaturated fats tend to have denser breasts 15 years later, new research suggests. That's important because greater breast density is a risk factor for breast cancer, the study authors said. But the researchers noted they didn't find a large change in breast density volume based on dietary fat intake. "It was a modest difference in breast density," the study's senior author said. While this study can't prove cause-and-effect, the researchers speculated that different fats may play different roles in breast tissue formation and maintenance. Teen years are a critical time for breast development, the study authors noted. Study author and her team reviewed data from the Dietary Intervention Study in Children. This clinical trial started in 1988, enrolling more than 600 children between ages 8 and 10. More than 300 of the children were girls. On multiple occasions, the participants reported details of their diets. Later, in a follow-up of the same group, the researchers used MRI scans to measure breast density in 177 female participants when they were ages 25 to 29. The researchers found that higher intakes of unhealthy fats and lower intake of healthy fats during adolescence were associated with an increased risk of denser breasts. Experts and organizations such as the American Heart Association (AHA) recommend that a healthy diet should contain about 5 percent saturated fat. Women who ate the most saturated fat during adolescence got about 13 percent of total calories from saturated fat. These women had an average breast density of 21.5 percent, the study found. Women who ate the least saturated fat -- about 8 percent of total calories from fat -- had a breast density of 16.4 percent. A similar difference was found for those who ate the lowest levels of healthy fats during the teen years compared to those who ate the highest levels. Eating more healthy fats was linked with less breast density, the study said. Study author said, "This is an initial study; it would need to be confirmed before making any recommendation [about diet]." The study appears in the June issue of the journal Cancer Epidemiology, Biomarkers & Prevention.

SOURCE: HealthDay News, May 2016

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 Weight & Ca-Colon !

                                                                A Little Excess Weight May Boost Colon Cancer Survival

In what may come as a bit of a surprise, a new study found that overweight colon cancer(Ca-colon) patients tended to have better survival than their normal-weight peers. "Overweight and obesity have been identified as risk factors for many health conditions, but for people with colorectal cancer, some extra weight may provide protection against mortality," study lead author said. Still, one health expert cautioned that the finding is no license for people to pile on excess pounds. In the study, research team examined the medical records of more than 3,400 people in California diagnosed with stages 1-3 colon cancer between 2006 and 2011. The researchers then compared each patient's risk of death at the time of diagnosis and then over the following 15 months. Patients who were either underweight or statistically obese at diagnosis were more likely to die than normal-weight patients, the study found. However, people who fell into the "overweight" -- but not obese -- category were 55 percent less likely to die from colon cancer and 48 percent less likely to die from any cause than normal-weight patients, the research team found. Prior research has shown that overweight and obese people are at higher risk for several types of cancers. However, they often have better cancer outcomes than normal-weight patients, something referred to as the "obesity paradox," the researchers noted. "Our study, which represents the largest cohort of colorectal cancer patients with the most comprehensive data regarding patient weight before, at time of, and following diagnosis, supports the notion of the 'obesity paradox,' " study author said. This is an observational study, however, so it cannot prove that weight helped cause (or shield against) death in these patients. The study was published May 19 in the journal JAMA Oncology.

SOURCE: HealthDay News, May 2016

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 Newer Drugs !

                                                                    Newer Drugs Helping Older People With Eye Disease

New medications are boosting quality of life for many older people with age-related macular degeneration (AMD), a new study indicates. The drugs Bevacizumab and Ranibizumab have significantly increased the number of people with AMD whose vision remains good enough to do daily activities, such as read standard print or drive, researchers found. Age-related macular degeneration is the leading cause of vision loss among older Americans, the U.S. National Eye Institute (NEI) says. Ten years ago, the best available treatment for AMD was photodynamic therapy, which used an intravenous drug and laser treatment to seal off leaking blood vessels in the eye that cause AMD, the researchers explained. However, one year after diagnosis, less than 15 percent of patients who received photodynamic therapy alone had 20/40 vision, which is typically good enough to read standard print or drive, the researchers said. Up to 40 percent of those treated with photodynamic therapy declined to 20/200 vision, according to the study authors. Without treatment, less than 10 percent of patients have 20/40 vision one year after diagnosis, and up to 75 percent have 20/200 vision, the researchers noted. The new study included nearly 650 patients with a form of AMD known as wet AMD. That means that abnormal blood vessels grow beneath the retina, and these new vessels leak fluid, the NEI said. The researchers found that 50 percent of the study volunteers had 20/40 vision or better after five years of treatment with Bevacizumab or Ranibizumab. These treatments are known as anti-VEGF drugs. VEGF is a protein that causes the abnormal blood vessels to grow in the eyes. The drugs are injected directly into the eye, the researchers said. Twenty percent of the patients in the study had 20/200 vision after five years of treatment with the anti-VEGF drugs, and the remainder were between 20/40 and 20/200, the study found. "This is the most comprehensive study of anti-VEGF therapy for AMD to date," NEI Director said. "It points to the importance of long-term follow-up in studies evaluating disease treatments." Study principal investigator said, "Although anti-VEGF treatment has greatly improved the prognosis for patients overall, we still need to find ways to avoid poor vision in these patients and to decrease the burden of ongoing treatment." The findings were published recently in the journal Ophthalmology.

SOURCE: HealthDay News, May 2016

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New Products of SQUARE Pharmaceuticals Ltd.

  Product Gol
  Generic Name Macrogol+Nacl+KCl+NaHCO3

13.125gm+350.7mg+46.6mg+178.5 mg

  Dosage form Oral Solution
  Therapeutic Category Laxative
Product Remac         
Generic Name


Strength 125 mg/5ml
Dosage form Powder for Suspension
Therapeutic Category Marcolide Antibiotic
  Product Viodin Solution 1 Litre
Generic Name Povidone Iodine
  Strength 10%
Dosage form Solution
  Therapeutic Category Antiseptic Disinfectant

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