Healthcare online Keeping you up-to-date
VOL.  10     ISSUE:  3    March 2012 Medical Services Department

SQUARE Pharmaceuticals Ltd.





P G Dip. Business Management

A. S. M. Shawkat Ali

MBBS, M. Phil





Dear Doctor:

Welcome to this edition of "e- SQUARE" healthcare bulletin !

This issue features a variety of articles including "Gum Disease !", "Bypass Surgery !", "Heart Trouble !", "Fertility & Cancer !", "HPV Vaccine !", "Depression Risk !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals Ltd. as well.

We welcome your feedback regarding "e-SQUARE" ! 

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Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE PHARMACEUTICALS LTD.

 Gum Disease !

Treating Gum Disease May Help Diabetics Avoid Complications

Treating gum disease in people with diabetes reduces their medical costs and hospitalizations, new research shows. The three-year study included diabetes patients with gum (periodontal) disease who were randomly selected either to receive periodontal therapy or no treatment (control group). Those in the treatment group underwent periodontal therapy in the first year and their gum health was maintained for the following two years. The patients in the control group had incomplete periodontal therapy before the study and did not receive regular periodontal maintenance during the study. The total annual per-patient cost of hospital admissions, doctor visits and overall medical care was an average of more than $1,800 lower in the treatment group than in the control group. The patients in the treatment group had 33 percent fewer hospital admissions. There have been emerging links between oral infections and systemic diseases such as diabetes, which is increasingly prevalent in our population, lead researcher said. This study provided direct insight as to how lower hospitalizations could be achieved through periodontal therapy, and we will further this study by analyzing other chronic diseases and conditions such as heart attacks, strokes and pregnancy with pre-term birth. It's also important to note that although the study showed an association between better gum care and lowered health costs for diabetics, it didn't prove that healthier gums directly resulted in fewer hospitalizations or lowered costs.

SOURCE: HealthDay News, March 2012 

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 Bypass Surgery !

Bypass Surgery May Be Better Than Angioplasty For Seniors

Patients over the age of 65 who have severe coronary artery disease fare better with bypass surgery than with minimally invasive angioplasty, a large, new study indicates. Although there was no significant difference in mortality after one year, patients who had undergone bypass surgery had a 21 percent reduced risk of dying after four years compared to those who had received angioplasty, the researchers found. The trend in cardiology more recently has been to favor angioplasty over surgery, explained study author. During angioplasty, cardiologists insert a small "balloon" into the blocked vessel via a catheter. Once in place, the balloon is inflated to widen the vessel. The procedure can be done with or without placing a stent, a wire mesh scaffold that keeps the vessel propped open. Coronary artery bypass surgery involves grafting part of a healthy vessel onto the blocked vessel to reroute blood flow, "bypassing" the blocked part of the vessel. Researchers combined information from two large databases which included about 200,000 patients, all elderly and all with more than one blood vessel blocked. About 86,000 underwent surgery and 104,000 had angioplasty. Of those who had angioplasty, 78 percent received drug-eluting stents, 16 percent received bare-metal stents and 6 percent had no stents.  Although the study was not a randomized, controlled trial considered the gold standard of medicine because those studies randomly assign people to different treatments and compares them with those who are untreated. Researcher said, the results probably can be extrapolated to other groups.

SOURCE: HealthDay News, March 2012

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 Heart Trouble !

CT Scans Can Spot Heart Trouble Fast

Most people who go to the emergency room (ER) with chest pain aren't having a heart attack, but it can take hours or days to make a definitive diagnosis. However, a new study finds that a special kind of CT scan seems to identify a heart attack faster than traditional methods, so patients can be sent home safely sooner. Researcher noted it can take 25 hours to get the results of blood tests that indicate whether a patient has had a heart attack but using the CT scan, diagnosis can be made faster. Two-thirds of heart attacks will have an EKG that's not diagnostic. For every 100 patients who go to ER with chest pain, only 10 or 15 have cardiac disease, the other 90 percent have nothing serious, researcher added. In addition, ERs are busy and crowded, and this is a way to move patients out faster and increase the ability to see more patients sooner. For the study, more than 1,300 patients assigned with chest pain, but no previous history of heart disease or risk factors such as high blood pressure or diabetes, to CT scans or regular care. The scans generate three-dimensional images of the heart and the blood vessels surrounding it. Among those with a normal scan, none died or had a heart attack within a month after being seen in the ER. In addition, more of these patients were sent home than those who received usual care about 50 percent versus 23 percent, the researchers found. Those who received scans spent less time in the hospital and had heart problems diagnosed faster. There has been great interest in developing strategies to more efficiently evaluate these patients and identify which ones can be safely discharged. The trial demonstrated that these scans may be useful to screen low- to moderate-risk patients. However, further studies are needed to evaluate the cost-effectiveness of this strategy and how it compares to protocols using high-sensitivity troponin tests, researcher added. However, this test is usually repeated over 12 to 16 hours, so the results do not come back as quickly as a CT scan.

SOURCE: HealthDay News, March 2012 

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 Fertility & Cancer !

Few Young Women With Cancer Take Steps To Preserve Fertility

Very few young women with cancer take measures to preserve their fertility while undergoing cancer treatment, a new study says. The findings suggest that reproductive-age women with cancer need more information about fertility preservation methods such as egg or embryo freezing, said the study author. The researchers surveyed 1,041 women aged 18 to 40 who were diagnosed with cancer between 1993 and 2007. Of those women, 918 received cancer therapies (chemotherapy, pelvic radiation, pelvic surgery, or bone marrow transplant) that could harm their fertility. 61% of the women received counseling from their doctors or other health care providers on the risks that cancer treatment posed to their fertility, but only 4 percent of the women actually took steps to preserve their fertility. The proportion of patients who took measures to preserve their fertility, however, increased from 1 percent in 1993 to between 6 percent and 10 percent in 2005 to 2007, according to the study. The researchers also found that women who were childless, younger, white, heterosexual and college graduates were more likely than women of other backgrounds both to be counseled about the fertility-related risks of cancer treatment and to preserve their fertility before undergoing cancer treatment. Although more women are getting counseled regarding reproductive health risks, many women are still not receiving adequate information about their options at the time of cancer diagnosis. Routine counseling regarding reproductive health risk and options for preserving reproductive potential will improve the overall quality of life & care. According to the American Cancer Society, steps to preserve fertility usually have to be taken before or during cancer treatment, meaning young women with cancer need to make decisions quickly. Freezing embryos is the most common, well-established option for women. But there are other methods, including freezing eggs or portions of ovarian tissue and choosing specific strategies for combating the cancer that spare the ovaries.

SOURCE: HealthDay News, March 2012

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 HPV Vaccine !

HPV Vaccine May Help Women With Cervical Conditions

 A new study finds that women diagnosed with pre-cancerous cervical conditions after they get the human papillomavirus (HPV) vaccine can still benefit from the shot because it cuts their risk of future HPV-related cervical disease. HPV remains the most common sexually transmitted infection  and can cause health problems ranging from genital warts to cervical cancer, according to the U.S. Centers for Disease Control and Prevention. HPV infection is thought to be the leading cause of cervical cancer and two HPV vaccines, Gardasil and Cervarix, have received FDA approval. Previous research has shown that HPV vaccination does not prevent progression to cervical pre-cancers in women who have an HPV infection when they receive the vaccine.  However, this is the first study to examine if HPV vaccination can prevent future cervical disease in these women after they've been successfully treated for their current condition, the researchers pointed out. The investigators analyzed data from 1,350 young women in 24 developed and developing countries who took part in two clinical trials in which they received either the HPV vaccine or an inactive placebo. The women were subsequently diagnosed with either a vulvar or vaginal disease (including genital warts) or had required cervical surgery. Among women who required cervical surgery after taking part in the studies, the risk of getting a subsequent HPV-related disease was 6.6 cases per 100 women per year among those who received the HPV vaccine and 12.2 cases per 100 women per year among those who received the placebo. This translates into more than a 46 percent reduced risk for women who received the HPV vaccine, the authors noted. The researchers also found that the risk of pre-cancerous changes of the cervix and other "high-grade" cervical disease was almost 65 percent lower in those who received the HPV vaccination than in those who received the placebo.  Among women who were diagnosed with and treated for vaginal or vulvar disease, the risk of any future HPV-related disease was about 35 percent lower among those who received the HPV vaccine than among those who received the placebo, the study authors reported.

SOURCE: Health Day News, March 2012

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 Depression Risk !

Living Alone Linked To Greater Risk Of Depression: Study

People who live alone have a nearly 80 percent greater risk of depression than those who live with others, new research suggests. Over the past three decades, the number of people living on their own in the United States has doubled, to one in three people. The study included 3,500 working-age men and women who were followed for seven years. The researchers looked at the participants' antidepressant use; living arrangements; and psychosocial, sociodemographic and health risk factors, such as smoking, heavy drinking and lack of exercise. In women, one-third of the increased risk of depression was linked to sociodemographic factors such as low income and lack of education, according to the study. The main risk factors for men included heavy drinking and a lack of support in the workplace or in their private lives. This kind of study usually underestimates risk because the people who are at the most risk tend to be the people who are least likely to complete the follow up, study author said. They also were not able to judge how common untreated depression was. More than half of the increased risk remains unexplained, the researchers noted. Possible factors may include feelings of alienation from society, lack of trust or difficulties caused by major life challenges. Although the study found an association between living alone and depression, it did not prove a case-and-effect relationship.

SOURCE: Health Day News, March 2012

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New Products of SQUARE Pharmaceuticals Ltd.

  Product Tebast
  Generic Name Ebastine
  Strength 10 mg
  Dosage form Tablet
  Therapeutic Category Antiallergy Preparations
  Product Sultolin Nebulizer Solution
Generic Name



2.5 mg/2.5 ml

Dosage form Nebulizer Solution
Therapeutic Category Nebulizer Preparations
  Product Ansulin
  Generic Name Insulin Human (rDNA) USP

100 IU/ml

  Dosage form Subcutaneous Injection
  Therapeutic Category Human Insulin

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