LebacTM

Cephradine
Cephalosporins (Penicillins and Cephalosporins)

Indication:
LebacTM(Cephradine) is used in the treatment of infections caused by sensitive organisms.
Upper respiratory tract infections: Pharyngitis, sinusitis, otitis media, tonsilitis,
laryngotracheo-bronchitis; Lower respiratory tract infections: Acute and chronic bronchitis,
lobar and bronchopneumonia. Urinary tract infections: Cystitis, urethritis, pyelonephritis; Skin
and soft tissue infections: Abscess, cellulitis, furunculosis, impetigo; Gastrointestinal tract
infections: Bacillary dysentery, enteritis, peritonitis. Bone and joint infection; Surgical
prophylaxis: It is also used in perioperative prophylactic administration (pre-operatively,
intra-operatively and post-operatively). In cesarean section, intra-operative (after clamping
the umbilical cord) and post-operative use may reduce the incidence of certain postoperative
infections.

Dosage & Administration:
The dosage may be given without regard to meals.


Adult:
Oral: The usual dose is 1-2 gm daily in 2 to 4 divided doses. In severe and prolonged
infection, the dose can be increased up to 4 gm daily which should be taken in equally
divided doses. Injection: The usual dose is 2-4 gm daily which should be given
intramuscularly or intravenously in 3-4 divided doses. Special dose in the following infections
: Skin and skin structures and respiratory tract infection: Usual dose is 250 mg every 6 hours
or 500 mg every 12 hours. Lobar pneumonia: 500 mg every 6 hours or 1 gm every 12 hours.
Urinary tract infection: Usual dose is 500 mg every 12 hours. Gastro-intestinal tract infection:
500 mg three to four times daily.


Children:
Oral: The usual total dose is 25 to 50 mg/kg/day given in 2 to 4 equally divided doses.
Injection: 50 to 100 mg/kg/day in 4 equally divided doses. The usual total dose may be
increased up to 200-300 mg/kg/day. Perioperative prophylaxis: Recommended dose is 1-2
gm by intramuscular or intravenous route; subsequent parenteral or oral doses are given as
appropriate. Therapy should be continued for a minimum of 48-72 hrs. after the patient
becomes asymptomatic or evidence of bacterial eradication has been obtained.
Dosage in renal impairment: In patients with impaired renal function, doses and frequency of
administration of cephradine must be modified according to the degree of impairment,
severity of infection, susceptibility of the causative organism and serum concentration of the
drug. For adults, a loading dose of 750 mg should be given subsequently followed by 500 mg
with the mentioned time interval....

Preparation:
LebacTM 250 Capsule: B ox containing 18 capsules in blister pack.
LebacTM 500 Capsule: B ox containing 30 capsules in blister pack.
LebacTM Powder for Suspension: Bottle containing dry powder to reconstitute 100 ml suspension with a measuring cup.
LebacTM Forte Powder for Suspension: Bottle containing dry powder to reconstitute 100 ml suspension with a measuring cup.
LebacTM 500 mg IM/IV Injection: Pack of 1 vial accompanied by 1 ampoule of 5 ml Water for injection BP for IM or IV injection. It also contains a complementary pouch comprised of disposable syringe (5 ml), baby needle, alcohol pad and first aid bandage.
LebacTM 1 gm IM/IV Injection: Pack of 1 vial accompanied by 1 ampoule of 10 ml Water for injection BP for IM or IV injection. It also contains a complementary pouch comprised of disposable syringe (10 ml), butterfly needle, alcohol pad and first aid bandage.
LebacTM Paediatr ic Drops: Bottle containing dry powder to reconstitute 15 ml drops with a 5 ml spoon & a dropper



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