Dosage & Administration:
Administer once daily with meal preferably in the evening. Gradually escalate the dose to reduce the gastrointestinal side effects due to Metformin. May adjust the dosing based on effectiveness & tolerability while not exceeding the maximum daily dose of 100 mg Sitagliptin & and 2000 mg Metformin extended-release. Maintain the same total daily dose when changing between Siglimet™ & Siglimet™ XR without exceeding the maximum recommended daily dose of 2000 mg Metformin extended-release. Patients using two Siglimet™ XR tablets (such as two Siglimet XR 50/500 or two Siglimet™ XR 50/1000 tablets) should take the two tablets together once daily. 100 mg Sitagliptin/2000 mg Metformin HCl XR tablets should be taken as a single tablet once daily.
Siglimet™ 50/1000 Tablet: Each box contains 20 tablets in blister pack.
Siglimet™ XR 50/500 Tablet: Each box contains 18 tablets in blister pack.
Siglimet™ XR 50/1000 Tablet: Each box contains 18 tablets in blister pack.
Siglimet™ XR 100/1000 Tablet: Each box contains 12 tablets in blister pack.