Tazocilin

Piperacillin and Tazobactam
Broad Spectrum Penicillin (Penicillin Antibiotic )

Indication:
Tazocilin IV infusion is indicated for the treatment of the following systemic and/or local bacterial infections: Nosocomial pneumonia (moderate to severe), Community-acquired pneumonia (moderate only), Uncomplicated and complicated skin and skin structure infections, including cellulitis, cutaneous abscesses and ischemic/diabetic foot infections, Postpartum endometritis or pelvic inflammatory disease, Appendicitis (complicated by rupture or abscess) and peritonitis. Tazocilin IV Infusion may also be used in the management of neutropenic patients (adults, adolescents and children) with fever suspected to be due to bacterial infections.

Dosage & Administration:
Piperacillin & Tazobactam should be administered by intravenous infusion over 30 minutes.
Adult Patients:
The usual total daily dose of Piperacillin & Tazobactam for adults is 3.375 gm every six hours totaling 13.5 gm (12.0 gm Piperacillin & 1.5 gm Tazobactam). The usual duration of treatment is from 7 to 10 days.
Nosocomial Pneumonia:
Initial presumptive treatment of patients with nosocomial pneumonia should start with Piperacillin & Tazobactam at a dosage of 4.5 gm every six hours plus an aminoglycoside, totaling 18.0 gm (16.0 gm Piperacillin & 2.0 gm Tazobactam). The recommended duration of treatment for nosocomial pneumonia is 7 to 14 days. Treatment with the aminoglycoside should be continued in patients from whom P. aeruginosa is isolated.
Renal Impairment:
In patients with renal impairment (creatinine clearance ˜ 40 mL/min) and dialysis patients (hemodialysis and CAPD), the intravenous dose of Piperacillin & Tazobactam should be reduced to the degree of actual renal function impairment. The recommended daily doses of Piperacillin & Tazobactam for patients with renal impairment are as follows:
All Indications (except nosocomial pneumonia):
Patients with creatinine clearance >40 mL/min: 3.375 gm 6 hourly
Patients with creatinine clearance 20-40 mL/min: 2.25 gm 6 hourly
Patients with creatinine clearance <20 mL/min: 2.25 gm 8 hourly
Hemodialysis* patients: 2.25 gm 12 hourly
In case of CAPD: 2.25 gm 12 hourly
Nosocomial pneumonia:
Patients with creatinine clearance >40 mL/min: 4.5 gm 6 hourly
Patients with creatinine clearance 20-40 mL/min: 3.375 gm 6 hourly
Patients with creatinine clearance <20 mL/min: 2.25 gm 6 hourly
Hemodialysis* patients: 2.25 gm 8 hourly
In case of CAPD: 2.25 gm 8 hourly
* 0.67 gm Piperacillin & 0.08 gm Tazobactam should be administered following each hemodialysis session on hemodialysis days.
Pediatric Patients:
For children with appendicitis and/or peritonitis 9 months of age or older, weighing up to 40 kg, and with normal renal function, the recommended dosage is 100 mg Piperacillin &12.5 mg Tazobactam per kg of body weight, every 8 hours. For pediatric patients between 2 months and 9 months of age, the recommended dosage based on pharmacokinetic modeling, is 80 mg Piperacillin & 10 mg Tazobactam per Kg of body weight, every 8 hours. Pediatric patients weighing over 40 kg and with normal renal function should receive the adult dose. It has not been determined how to adjust Piperacillin & Tazobactam dosage in pediatric patients with renal impairment.

Preparation:
Tazocilin 2.25 IV infusion: Each combipack contains one vial of Tazocilin 2.25 IV infusion and 1 bottle of 50 ml normal saline (Solo ), one disposable syringe(10 ml), one infusion set, one baby needle, one alcohol prep. pad, and one first aid band.
Tazocilin 4.5 IV infusion: Each combipack contains one vial of Tazocilin 4.5 IV infusion and 1 bottle of 100 ml normal saline (Solo ), one disposable syringe (20 ml), one infusion set, one butterfly needle, one alcohol prep. pad, and one first aid band.



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