- Invasive aspergillosis
- Candidemia in non-neutropenics and other deep tissue Candida infections
- Esophageal candidiasis
- Serious fungal infections caused by Scedosporiumapiospermum and Fusariumspecies including Fusariumsolani, in patients intolerant of or refractory to othertherapy
Dosage & Administration:
For Patients 40 kg or above
Loading Dose: 400 mg twice daily (for the first 24 hours)
Maintenance Dose: 200 mg twice daily (from the 2nd day)
For Patients less than 40 kg
Loading Dose: 200 mg twice daily (for the first 24 hours)
Maintenance Dose: 100 mg or 150 mg twice daily (from the 2nd day)
For adults: If patient response is inadequate, the oral maintenance dose may be increased from200 mg to 300 mg every 12 hours. For adult patients weighing less than 40 kg, the oralmaintenance dose may beincreased from 100 mg to 150 mg every 12 hours. Ifpatients are unable to tolerate 300 mg orally every 12 hours, reduce the oralmaintenance dose by 50 mg steps to a minimum of 200 mg every 12 hours (or to 100mg every 12 hours for adult patients weighing less than 40 kg).
Treatment duration depends upon patients’ clinical and mycological response.