Dosage & Administration:
The usual total daily dose of Piperacillin & Tazobactam for adults is 3.375 gm every six hours totaling 13.5 gm (12.0 gm Piperacillin & 1.5 gm Tazobactam). The usual duration of treatment is from 7 to 10 days.
Initial presumptive treatment of patients with nosocomial pneumonia should start with Piperacillin & Tazobactam at a dosage of 4.5 gm every six hours plus an aminoglycoside, totaling 18.0 gm (16.0 gm Piperacillin & 2.0 gm Tazobactam). The recommended duration of treatment for nosocomial pneumonia is 7 to 14 days. Treatment with the aminoglycoside should be continued in patients from whom P. aeruginosa is isolated.
In patients with renal impairment (creatinine clearance ˜ 40 mL/min) and dialysis patients (hemodialysis and CAPD), the intravenous dose of Piperacillin & Tazobactam should be reduced to the degree of actual renal function impairment. The recommended daily doses of Piperacillin & Tazobactam for patients with renal impairment are as follows:
All Indications (except nosocomial pneumonia):
Patients with creatinine clearance >40 mL/min: 3.375 gm 6 hourly
Patients with creatinine clearance 20-40 mL/min: 2.25 gm 6 hourly
Patients with creatinine clearance <20 mL/min: 2.25 gm 8 hourly
Hemodialysis* patients: 2.25 gm 12 hourly
In case of CAPD: 2.25 gm 12 hourly
Patients with creatinine clearance >40 mL/min: 4.5 gm 6 hourly
Patients with creatinine clearance 20-40 mL/min: 3.375 gm 6 hourly
Patients with creatinine clearance <20 mL/min: 2.25 gm 6 hourly
Hemodialysis* patients: 2.25 gm 8 hourly
In case of CAPD: 2.25 gm 8 hourly
* 0.67 gm Piperacillin & 0.08 gm Tazobactam should be administered following each hemodialysis session on hemodialysis days.
For children with appendicitis and/or peritonitis 9 months of age or older, weighing up to 40 kg, and with normal renal function, the recommended dosage is 100 mg Piperacillin &12.5 mg Tazobactam per kg of body weight, every 8 hours. For pediatric patients between 2 months and 9 months of age, the recommended dosage based on pharmacokinetic modeling, is 80 mg Piperacillin & 10 mg Tazobactam per Kg of body weight, every 8 hours. Pediatric patients weighing over 40 kg and with normal renal function should receive the adult dose. It has not been determined how to adjust Piperacillin & Tazobactam dosage in pediatric patients with renal impairment.
Tazocilin™ 4.5 IV infusion: Each combipack contains one vial of Tazocilin™ 4.5 IV infusion and 1 bottle of 100 ml normal saline (Solo™ ), one disposable syringe (20 ml), one infusion set, one butterfly needle, one alcohol prep. pad, and one first aid band.